Ying Si1
Bo Sun- 1Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 2Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, Luzhou, China
Focal nodular hyperplasia (FNH) of the liver is a benign lesion characterized by hypertrophic nodules with central star-shaped fibrous scars. The etiology and pathogenesis of FNH are not completely understood. A 43-year-old man was hospitalized because of acute abdominal pain. Emergency computed tomography(CT) showed hepatic tumor rupture and bleeding. The patient’s condition improved following arteriographic embolization to stop bleeding. Laparotomy confirmed spontaneous rupture and hemorrhage of focal hyperplasia and the patient remains asymptomatic after an uneventful recovery. FNH with spontaneous rupture and bleeding is extremely rare. Currently, there is no unified management standard for FNH and most previous studies recommend observation and follow-up. We recommend consideration of surgical treatment of cases with spontaneous rupture and bleeding.
Introduction
Focal nodular hyperplasia (FNH) is the second most common benign liver tumor and accounts for approximately 8% of all primary hepatic tumors. It is thought to be a hyperplastic response to increased blood flow in an arterial malformation rather than a true neoplasm (1, 2). Spontaneous hemorrhage of an FNH is very rare, and only 10 cases have been reported (3). This patient with spontaneous rupture and bleeding of a FNH in the right liver was successfully treated by second step surgical treatment.
Case presentation
A 43-year-old Chinese man was admitted to the hospital because of acute abdominal pain. He had no history of trauma, was in good health, and had been an intermittent alcohol user for about 20 years. Physical examination revealed no palpable mass or tenderness in the right upper abdomen. Blood routine showed that Hemoglobin was 142g/L.Alanine aminotransferase(502.6/U/L)and aspartate aminotransferase(527.9/U/L)were significantly increased. Blood coagulation tests and tumor-marker levels were normal. Abdominal enhanced computed tomography (CT) showed a round, approximately8.0cm×8.0cm mass with a slightly blurred border in the right lobe of the liver, and blood around the liver. A tumor hemorrhage was suspected (Figure 1) and as continued bleeding could not be ruled out, the patient underwent hepatic arteriographic embolization in the emergency department. Intraoperative angiographic findings the tumor was stained in irregular mass, with irregular outer border and widened perihepatic shadow. During the operation, lipiodol and gelatin sponge particles were used to embolize the responsible blood supply artery of the tumor. Re-imaging after embolization showed that the imaging of tumor supplying arteries was significantly reduced, the tumor staining range was significantly reduced, and the embolic agent was well deposited and the patient’s condition improved after 2 weeks of conservative treatment. After preoperative and intraoperative evaluation, the patient underwent right hemihepatectomy. Intraoperative exploration revealed that most of the tumor was located in segment VII and VIII, and a small part was located in segment V, adjacent to the right hepatic artery. Tumor size is about 8.0cm×8.0cm cm with an incomplete capsule, the boundary was clear, and an old blood accumulation was seen around the liver. The resected tumor was round, with clear boundaries and contained a hematoma. Pathologic examination of hematoxylin–eosin-stained tissue showed hepatocyte proliferation and vasodilation, and no atypical hyperplasia (Figures 2). Immunohistochemistry showed focally positive CK19 and CD34 cells consistent with capillary formation (Figures 3). The pathological features resulted in a final diagnosis of FNH with spontaneous rupture and bleeding. The patient recovered uneventfully and remains asymptomatic for 2 years. Figure 4, 5, 6
Figure 1 Emergency CT of the abdomen showed a mixed density mass of about 8*8 cm in the right lobe of the liver. The lesion was near the right hepatic artery and free liquid density was visible around it.
Figure 2 The tumor is nodular to the naked eye, and the cut surface is grayish yellow, and blood is visible.
Figure 3 Hematoxylin-eosin staining showed hepatocyte proliferation and vasodilation, and no atypical cells.
Figure 4 Hematoxylin-eosin staining showed hepatocyte proliferation and vasodilation, and no atypical cells.
Figure 5 Immunohistochemistry showed CK19 (focal +).
Figure 6 Immunohistochemistry showed CD34(+).
Discussion
FNH is the second most prevalent benign liver tumor after hepatic cavernous hemangioma. The incidence is highest in those 20–50 years of age, but FNH can occur at any age (4, 5). It most often occurs in women of childbearing age with a history of oral contraceptives (6, 7). The etiology is not fully understood, but vascularization by an anomalous artery, reactive hyperplasia after hepatocellular injury induced by vasculitis, or aberrant, increased blood flow have been implicated (8–10).
Previous cases of FNH with intraperitoneal hemorrhage, including this patient, reported in English-language publications are shown in Table 1 (3, 14–20). This review reviewed 11 patients, including 2 males and 9 females. The incidence was mainly female, with an average age of 31.7 years. As most FNH patients have no symptoms, most lesions are found by accident. Most symptomatic patients present with abdominal pain, discomfort in the right upper abdomen, and nausea. Very few have palpable masses (21–26). Liver enzyme values are abnormal in the serum of 10% to 14% of patients (27).Abdominal ultrasound, CT, and magnetic resonance imaging (MRI) with radioactive labels may reveal star scars (28).MRI has higher sensitivity and specificity for diagnosis of FNH than CT and abdominal ultrasound, especially magnetic resonance cholangiopancreatography (29, 30). Contrast-enhanced ultrasound with sonazoid may provide hemodynamic information of the vascular pattern and Kupffer-phase imaging improves diagnostic confidence and is effective for follow-up in clinical practice (31).
Table 1 Documented patients of hemorrhage caused by FNH.
The occurrence of spontaneous rupture and bleeding of FNH might be explained as follows: Bleeding in FNH patients may be the result of vascular malformations and intratumoral pressure associated (2, 9, 10). Increased intratumoral pressure compresses the malformed blood vessels, eventually leading to results in spontaneous bleeding. For this patient, he had a history of alcoholic hepatitis, and the liver tissue was fragile. The tumor was located around the liver and adjacent to the right hepatic artery and was large and vulnerable to external force. Therefore, the combined effect of the above factors may have caused the rupture of the tumor.
Nguye et al. (32) described FNH as having two pathologies classical and non-classical. Non-classical FNH includes telangiectasia, mixed hyperplasia, and adenoma-like characteristics. Classical FNH accounts for the vast majority of diagnoses. Fabre et al. (33) proposed FNH histology scoring criteria including four main characteristics (fibrous elements, thick-walled blood vessels, hyperplastic small bile ducts, and nodules) and two minor characteristics (dilatation of liver blood sinuses and sinus fibrosis). FNH can be diagnosed if three of the four main characteristics, two main characteristics, and one or two minor characteristics are present. The presence of two or fewer major characteristics does not support a diagnosis of FNH. FNH currently has no specific immunohistochemical markers. CK19 and CK56 are markers of liver precursor cells and bile duct epithelium and CK7 is a marker of immature hepatocytes. The combined use of CK7 and CK19 is helpful for the diagnosis of FNH. CD34 is a marker of vascular endothelium, and because dilated arteries with thick walls or cavernous hemangioma occur in FNH lesions, CD34 staining is often positive. CD19 is a membrane antigen associated with cell proliferation. FNH is a local vascular malformation of the liver with increased perfusion that results in abnormal proliferation of local hepatocytes and formation of nodular lesions. Therefore, CD19 staining is often positive. There are reports in the literature that β-catenin can activate glutamine synthetase (GS), which results in typical map-like staining. Therefore, GS staining may assist in the diagnosis of FNH (34, 35).
At present, there is no consensus on the standard treatment of FNH, which is a benign lesion with no underlying malignancy. Most recommendations are for follow-up of asymptomatic patients (36). Surgery is the mainstay of treatment for patients with symptoms, enlarged lesions, and imaging indeterminate lesions during follow-up. Rupture and bleeding of liver tumors is a life-threatening condition. Emergency arteriographic embolization of unexplained hepatic mass hemorrhage can successfully control bleeding in 99% of patients (13). After the patient’s condition improves, the second-stage mass can be removed and the condition diagnosed. In our experience, combined first-stage interventional embolization and second-stage mass resection can be used as the standard treatment for FNH rupture and bleeding.
Conclusion
Spontaneous rupture and bleeding of FNH is very rare, but should be fully considered in patients who experience sudden abdominal pain during follow-up.
Data Availability Statement
The original contributions presented in the study are included in the article/Supplementary Material. Further inquiries can be directed to the corresponding author.
Ethics Statement
Written informed consent was obtained from the participant for the publication of this case report.
Author Contributions
YS wrote all drafts. BS discussed the meaning of the draft. TZ and KX collect all the references. D-XZ carried out the pathology and collected the clinical data. Y-MH offered conception and finalized the draft. All authors read and approved the final manuscript.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Abbreviations
FNH, Focal nodular hyperplasia; CT, Computed tomography; MRI, magnetic resonance imaging; CEUS, contrast-enhanced ultrasound; GS, glutamine synthetase; RFA, radiofrequency ablation; TAE, transarterial embolization; PVA, polyvinyl alcohol.
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Keywords: focal nodular hyperplasia (FNH), liver, rupture, acute abdomen, surgery
Citation: Si Y, Sun B, Zhao T, Xiao K, Zhao D-X and Huang Y-M (2022) Case Report: Rare Acute Abdomen: Focal Nodular Hyperplasia With Spontaneous Rupture. Front. Oncol. 12:873338. doi: 10.3389/fonc.2022.873338
Received: 10 February 2022; Accepted: 20 June 2022;
Published: 13 July 2022.
Edited by:
Kun Zhang, Tongji University, ChinaReviewed by:
Alessio Vagliasindi, Santa Maria delle Croci Hospital, ItalyJose M. Ramia, Hospital General Universitario de Alicante, Spain
Copyright © 2022 Si, Sun, Zhao, Xiao, Zhao and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yong-Mao Huang, huang5616@sina.com