Elevated triglyceride-glucose index predicts mortality following endovascular abdominal aortic aneurysm repair
Tan Li
Chao Yang
Jun Yang
Jingjing Jing
Chunyan Ma1,2*- 1Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, China
- 2Clinical Medical Research Center of Imaging in Liaoning Province, The First Hospital of China Medical University, Shenyang, China
- 3Department of Burns, Trauma Center, The First Hospital of China Medical University, Shenyang, China
- 4Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China
Background: Triglyceride-glucose (TyG) index has been increasingly studied as a simple and reliable predictor of adverse events of some cardiovascular disorders. However, its prognostic effect on postoperative outcomes in patients with abdominal aortic aneurysm (AAA) is still unknown. The current study aimed to explore the potential role of TyG index in predicting mortality of AAA patients following endovascular aneurysm repair (EVAR).
Materials and methods: This retrospective cohort study analyzed the preoperative TyG index in a total of 188 AAA patients who underwent EVAR with the follow-up of 5 years. Data were analyzed with SPSS software Version 23.0. Association between the TyG index and all-cause mortality was evaluated using Cox regression models and Kaplan-Meier method.
Results: Cox regression analyses showed that per 1-unit increment of TyG index was significantly associated with an increased risk of postoperative 30-day, 1-year, 3-year, and 5-year mortality, even after adjustment for potential confounders (all P<0.05). Kaplan-Meier analysis suggested that patients with high TyG index (≥8.68) had a worse overall survival (P = 0.007).
Conclusion: The elevated TyG index could be a promising predictive factor of postoperative mortality in AAA patients after EVAR.
Introduction
Abdominal aortic aneurysm (AAA) is an irreversible progressive widening of the abdominal aorta and endovascular aneurysm repair (EVAR) intervention is regarded as a safe and effective method of treating AAA (1). Reliable preoperative risk factor detection makes it possible to early predict poor outcomes of AAA patients after surgery in clinical practice. The triglyceride-glucose (TyG) index, a product of fasting triglyceride (TG) and fasting plasma glucose (FPG), is considered to be a simple, cost-effective, valid and reliable surrogate marker for insulin resistance (IR) (2, 3). IR plays a crucial role in the pathogenesis of cardiovascular disease and has been established as a predictor of elevated mortality (4). Recently, several investigations discovered that the high TyG index might be an independent risk factor for all-cause mortality in patients with a variety of cardiovascular disorders (5, 6). For example, acute myocardial infarction and coronary angiography patients with a high TyG index owned a higher risk of all-cause mortality (5). Survival of AAA patients following EVAR may be influenced by age, some inflammatory biomarkers such as white blood cell (WBC) and C-reactive protein (CRP), and comorbidities like diabetes, renal insufficiency and stroke (7, 8). However, the predictive value of TyG index on early and late mortality of AAA patients after EVAR surgery remains unclear.
In this research, we intended to examine whether there was an association between the TyG index and all-cause mortality in AAA patients who received EVAR treatment. Our results may provide ideas for improving AAA risk stratification and clinical decision-making.
Materials and methods
This retrospective cohort study included 188 AAA patients undergoing EVAR in the First Hospital of China Medical University between February 2015 and November 2017. All patients were diagnosed by computed tomography angiography and successfully followed up for 5 years with complete preoperative fasting TG and FPG levels obtained upon hospital admission. The TyG index was calculated with the following formula: TyG index = Ln [fasting TG (mg/dL) × FPG (mg/dL)/2] (9). The subjects with previous aortic surgery, congenital disorder, malignant tumor, hematological disease or unavailable survival time were excluded. Baseline demographics, clinical information and laboratory data were obtained from hospital electronic medical records. A clinical follow-up was performed via telephone or medical records, and the primary outcomes were all-cause mortality during the follow-up period (30 days, 1 year, 3 years, and 5 years after EVAR). We completed the last follow-up visits on November 8, 2022. The study was approved by the Ethics Committee of the First Hospital of China Medical University (Shenyang, China).
Analyses were conducted with SPSS software Version 23.0. Categorical variables were reported in numbers and percentages and continuous variables were expressed as mean ± standard deviation. The differences of TyG index between groups were analyzed using Student's t-test. Univariate Cox regression analyses were utilized to identify the factors associated with mortality and variables with univariate P < 0.10 were included in the multivariate model for adjustment. We applied the unadjusted and adjusted Cox proportional hazards model to estimate the correlation between TyG index and all-cause mortality, and results were described by hazard ratios (HRs) with 95% confidence intervals (CIs). The optimal cut-point for the TyG index was determined based upon receiver operating characteristic (ROC) analysis. Kaplan-Meier survival analysis with the log-rank test was carried out to estimate the cumulative probability of survival. The statistical significance was defined as a P-value (two-sided) < 0.05.
Results
During the follow-up period of 5 years, a total of 42 patients died with an overall mortality rate of 22.3%. Patients who died had a higher preoperative TyG index than those who survived (8.88 ± 0.80 vs. 8.56 ± 0.59, P = 0.004). As presented in Table 1, body mass index (BMI), heart rate, diabetes, WBC and CRP were possible risk factors for 30-day mortality in AAA patients after EVAR. Meanwhile, age, stroke, renal insufficiency, diabetes, WBC and CRP might be related to 1-year mortality, and age, diabetes, WBC, D-dimer and CRP were potential confounding factors for 3- and 5- year mortality.
Table 1. Univariate Cox regression analyses of factors associated with mortality following EVAR for AAA during follow-up.
The significant association between the TyG index and postoperative mortality was found in both univariate and adjusted regression models (Table 2). Under Cox regression with multiple adjustments, per 1-unit increment of TyG index remained to have a relationship with a 3.015-, 2.848-, 2.524-, and 2.560-fold greater risk for 30-day, 1-year, 3-year, and 5-year mortality, respectively (all P < 0.05; Table 2).
Table 2. The association between the TyG index and postoperative mortality of AAA patients.
The ROC analysis determined that the predictive cutoff value of the TyG index for overall mortality was 8.68, yielding an area under the curve of 0.626 (95% CI = 0.529–0.723, P = 0.013). Kaplan-Meier analysis indicated that patients with high TyG index (≥8.68) suffered worse cumulative survival than those with low TyG index (<8.68; P = 0.007; Figure 1).
Figure 1. Kaplan-Meier curves of the cumulative survival probability according to TyG index above and below a cutoff value of 8.68.
Discussion
To the best of our knowledge, this was the first analysis to assess the effect of TyG index on clinical outcomes in AAA patients following EVAR, with a focus on both short-term and long-term mortality. According to the results, we demonstrated that an increase in the TyG index was significantly correlated with a higher risk of 30-day, 1-year, 3-year, and 5-year mortality, independent of potential risk factors. The survival probability in the TyG index ≥ 8.68 group was markedly lower than that in the TyG index <8.68 group. These findings highlight the usefulness of this simple and easy-to-calculate index to early identify AAA subjects at high risk of developing severe condition after EVAR therapy.
It should be noted that about 80.9% of AAA patients in the present cohort are males, which may be ascribed to the fact that AAA is a complex condition primarily affecting older men with an approximate 6:1 prevalence in males relative to females, and various studies support the protective role of estrogen against AAA (10, 11). Currently, the differential of the TyG index has come into focus to elucidate its role in the prognosis of patients with several forms of cardiovascular disease. It has been reported that higher TyG values were linked with an enhanced risk of adverse cardiovascular events in ST-elevation myocardial infarction patients who underwent percutaneous coronary intervention (12). Zhou et al. found that a TyG index >8.7 was connected to a higher risk of all-cause mortality in individuals with ischemic stroke (6). Notably, we discovered a similar threshold value of around 8.7 for elevated risk of mortality in patients after AAA repair.
Although the exact mechanism underlying the interaction between the TyG index and poor outcomes is not fully understood, it may be explained as follows. First, TyG index is a reliable indicator to evaluate IR. Previous evidence has suggested that IR can favor AAA initiation and progression (13). Moreover, IR usually leads to increased systemic and tissue inflammation, oxidative stress, endothelial dysfunction and renin-angiotensin-aldosterone system activation, thereby resulting in cell damage and affecting the longevity of individual's life (3, 14, 15). Second, TyG is usually associated with lipid and glucose metabolism disturbance, reflecting well the fat toxicity and sugar toxicity that can adversely affect cardiovascular outcomes (16, 17). In addition, a higher TyG index is independently related to the occurrence and development of arterial stiffness, nephric microvascular damage and several diseases including hypertension, diabetes, stroke, coronary artery disease, non-alcoholic fatty liver and malignancy, which are identified as risk factors for early and late mortality in AAA patients after EVAR (4, 17–19). Therefore, it seems reasonable to propose that AAA subjects with higher TyG levels are more likely to experience a course of vascular and organ impairment, contributing to an increased risk of all-cause mortality after EVAR. In clinical practice, our findings may guide clinicians to normalize the preoperative glucose or triglyceride under a target range, which is conducive to a good prognosis for patients with AAA repair.
Some limitations should be acknowledged. First, the TyG index was only collected at baseline and its changes during follow-up were not measured. Second, some influence of selection bias could not be excluded. Third, this was a single-center study based on a relative small cohort. Larger multicenter studies are necessary to confirm our results and define the causal effects of elevated TyG with mortality following EVAR for AAA.
In summary, TyG index could serve as a novel independent predictor for all-cause mortality in AAA patients after EVAR surgery and we also determined a specific cutoff value of TyG relevant to increased mortality. The detection of the TyG index may benefit the early risk stratification and clinical intervention to prevent postoperative all-cause death events.
Data availability statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors.
Ethics statement
The studies involving human participants were reviewed and approved by the Ethics Committee of the First Hospital of China Medical University (Shenyang, China). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.
Author contributions
TL, JJ, and CM: designed the study and interpreted the findings and revised the manuscript. TL: analyzed data and wrote the manuscript. TL and CY: carried out the study. CY and JY: did clinical data collection. All authors contributed to the article and approved the submitted version.
Funding
This work was supported by grants from the National Natural Science Foundation of China (82001828), Department of Science & Technology of Liaoning Province (2021JH1/10400051), and the National Natural Science Foundation of China (U21A20387).
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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Keywords: triglyceride, glucose, abdominal aortic aneurysm, biomarker, mortality
Citation: Li T, Yang C, Yang J, Jing J and Ma C (2023) Elevated triglyceride-glucose index predicts mortality following endovascular abdominal aortic aneurysm repair. Front. Nutr. 10:1116425. doi: 10.3389/fnut.2023.1116425
Received: 05 December 2022; Accepted: 30 January 2023;
Published: 13 February 2023.
Edited by:
Qinghui Ai, Ocean University of China, ChinaReviewed by:
Weiwei Dai, Fudan University, ChinaJingwei Liu, University of California, Riverside, United States
Copyright © 2023 Li, Yang, Yang, Jing and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Jingjing Jing, 
hellojjjing@163.com; Chunyan Ma, macy@cmu1h.com
†These authors have contributed equally to this work