Altered functional connectivity in individuals with loss of control eating.
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1
Drexel University, United States
Eating disorders (ED) are difficult to treat. A better understanding of ED etiology would help inform treatment and prevention. Loss of control eating (LOC), a sense of not being able to stop or control eating, accompanies binge eating in individuals with bulimia nervosa (BN) or binge eating disorder (BED). Additionally, LOC can be an early marker of eating-related psychopathology in children. Few studies have examined brain network alterations related to LOC. A better understanding of the early neural-behavioral correlates of eating disorder symptoms can help identify who might be at risk of future disease development or increased severity. This study examined whole brain functional connectivity using resting state fMRI in individuals with LOC. The sample included male and female individuals who did (n=49) or did not (n=49) endorse LOC (matched for age and gender), assessed by a yes or no response to the diagnostic question, “Has there been a time when your eating was out of control?”. Participants were aged 10-20 years and part of the 1445 Philadelphia Neurodevelopmental Cohort that underwent neuroimaging. Individuals reporting LOC (vs. no LOC) demonstrated disturbances in resting state functional connectivity between several frontoparietal regions and regions associated with the default mode network, visual processing (e.g. lateral occipital gyrus), and appetitive behavior (e.g. frontal operculum). These findings are consistent with the idea that individuals with LOC have dysfunction of self-regulation over their intrinsic state and sensory processing. These findings provide the first insights into the neural basis of LOC individuals’ difficulty controlling appetitive drive and their poor control and distorted perceptions of the state of their body; traits that often characterize individuals with eating disorders.
Keywords:
functional connectivity,
resting state fMRI,
Eating Disorders,
loss of control (LOC),
eating-related psychopathology
Conference:
2nd International Neuroergonomics Conference, Philadelphia, PA, United States, 27 Jun - 29 Jun, 2018.
Presentation Type:
Poster Presentation
Topic:
Neuroergonomics
Citation:
Benson
L,
Osipowicz
K,
Zhang
F and
Lowe
MR
(2019). Altered functional connectivity in individuals with loss of control eating..
Conference Abstract:
2nd International Neuroergonomics Conference.
doi: 10.3389/conf.fnhum.2018.227.00112
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Received:
13 Apr 2018;
Published Online:
27 Sep 2019.
*
Correspondence:
Ms. Leora Benson, Drexel University, Philadelphia, United States, leorabenson@gmail.com