Abnormal distribution of B-cell populations associated with impaired regulatory functions in the Chronic Antibody Mediated Rejection.
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1
Laboratory of Immunology and Pathology EA2216, France
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2
Department of Nephrology, Cavale Blanche, France
In kidney transplantation, the composition of the B cell compartment is increasingly being identified as an important determinant for graft outcome. Whereas naïve and transitional B cells have been associated with long term allograft survival and operational tolerance, memory B cells have been linked to graft rejection and graft loss. Chronic antibody mediated rejection (cABMR) now represents a major complication in transplantation and is a challenge in current therapeutics. In this study, we show that patients with cABMR display a unique B cell phenotype with a reduction in the ratio of "activated B cells"/"memory B cells" associated with an impaired immunosuppressive activity. We further show that the regulatory functions of B cells depend on their maturation status. We established that "activated B cells" were able to induce the expansion of regulatory T cells and to mediate durable suppressive function on autologous T cell proliferation through a TGFb/IDO axis, that was deficient in B cells from cABMR patients. Phenotypic and functional analysis of the B cell compartment could be indicated for appropriate follow-up after transplantation and drive therapy in the establishment of transplant tolerance processes.
Keywords:
Regulatory B-cells,
Kidney Transplantation,
IDO,
Chronic Antibody Mediated Rejection,
Suppressive Functions
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Nouël
A,
Segalen
I,
Grall
A,
Pers
J,
Le Meur
Y and
Hillion
S
(2013). Abnormal distribution of B-cell populations associated with impaired regulatory functions in the Chronic Antibody Mediated Rejection..
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00874
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Received:
18 Jun 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Mr. Alexandre Nouël, Laboratory of Immunology and Pathology EA2216, Brest, France, alexandre.nouel@gmail.com