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ANİ İŞİTME KAYIPLI HASTALARDA RUTİN HEMOGRAM İÇİNDEKİ İNFLAMATUAR MARKIRLARIN PROGNOZA ETKİSİ

Yıl 2021, Cilt: 9 Sayı: 1, 130 - 139, 25.03.2021

Mehmet Tan Deniz Uğur Cengiz Oguz Karakaş Tuba Bayindir

https://doi.org/10.33715/inonusaglik.847420
Cited By: 1

Öz

Bu çalışma; ani işitme kayıplı (AİK) hastaların hemogram sonuçlarının hastalığın derecesi ve prognozuna etkisini değerlendirmektedir. Çalışmaya, 2015-2020 yılları arasında kliniğimizde AİK tanısı konulan 325 hastanın 70’i dâhil edildi. Hastaların tedavi öncesindeki rutin hemogram parametreleri ve işitme testleri incelendi. Hastalar ile benzer özelik taşıyan sağlıklı bireylerden kontrol gurubu oluşturuldu. Hastalar işitme kaybı derecesi kaybına göre de 3 guruba ayrıldı. Çalışmamızda; hemoglobin, trombosit hacmi (MPV), platelet, nötrofil, nötrofil lenfosit oranı (NLO) ve platelet lenfosit oranı (PLO), platelet x nötrofil / lenfosit (PxN/L) değerleri karşılaştırıldı. AİK’lı gurup ile kontrol gurubu arasında hemoglobin, nötrofil, lenfosit, MPV, PLO, NLO, PxN/Ldeğerleri açısından istatiksel fark saptandı. Hastalığın tanı aşamasında yapılan rutin ve ucuz bir tetkik ile AİK tanısında ve prognozunda bu parametreler yeni bir belirteç olarak kullanılabilir.

Anahtar Kelimeler

Ani işitme kaybı hemogram platelet

Kaynakça

  • Akopuz, A., Turan, V., Özcan, A., Kopuz, Y., Toz, E., Kurt, S. (2016). A novel marker for the assessment of the treatment result in pelvic inflammatory disease. Minerva ginecologica, 68(2), 117-123.
  • Balta, S., Demirkol, S., Küçük, U. (2013). The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice. Hemodialysis International, 4(17), 668-669.
  • Boyraz, İ., Koç, B., Boyacı, A., Tutoğlu, A., Sarman, H., Özkan, H. (2014). Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. International journal of clinical and experimental medicine, 7(9), 2912.
  • Braekkan, S., Mathiesen, E., Njølstad, I., Wilsgaard, T., Størmer, J., Hansen, J. (2010). Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study. Journal of Thrombosis and Haemostasis, 8(1), 157-162.
  • Cadoni, G., Agostino, S., Manna, R., De Santis, A., Fetoni, A. R., Vulpiani, P., . . . Ottaviani, F. (2003). Clinical associations of serum antiendothelial cell antibodies in patients with sudden sensorineural hearing loss. The Laryngoscope, 113(5), 797-801.
  • Caligiuri, G., Nicoletti, A. (2006). Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour. In: The University of Chicago Press.
  • Chau, J. K., Lin, J. R., Atashband, S., Irvine, R. A., Westerberg, B. D. (2010). Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. The Laryngoscope, 120(5), 1011-1021.
  • Chu, S., Becker, R., Berger, P., Bhatt, D., Eikelboom, J., Konkle, B., . . . Berger, J. (2010). Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis. Journal of Thrombosis and Haemostasis, 8(1), 148-156.
  • Cook, E. J., Walsh, S. R., Farooq, N., Alberts, J. C., Justin, T. A., Keeling, N. J. (2007). Post-operative neutrophil–lymphocyte ratio predicts complications following colorectal surgery. International Journal of Surgery, 5(1), 27-30.
  • Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., . . . Maguire, P. B. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103(6), 2096-2104.
  • Durmuş, K., Terzi, H., Karataş, T. D., Doğan, M., Uysal, I. Ö., Sencan, M., . . . Altuntaş, E. E. (2016). Assessment of hematological factors involved in development and prognosis of idiopathic sudden sensorineural hearing loss. Journal of Craniofacial Surgery, 27(1), e85-e91.
  • Gary, T., Pichler, M., Belaj, K., Hafner, F., Gerger, A., Froehlich, H., . . . Pilger, E. (2013). Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PloS one, 8(7), e67688.
  • Hiramatsu, M., Teranishi, M., Uchida, Y., Nishio, N., Suzuki, H., Kato, K., . . . Suzuki, H. (2012). Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. Journal of Neurogenetics, 26(3-4), 387-396.
  • Imtiaz, F., Shafique, K., Mirza, S. S., Ayoob, Z., Vart, P., Rao, S. (2012). Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine, 5(2), 1-6.
  • Kallinen, J., Laippala, P., Laurikainen, E., Grénman, R. (1997). Sudden deafness: a comparison of anticoagulant therapy and carbogen inhalation therapy. Annals of Otology, Rhinology ve Laryngology, 106(1), 22-26.
  • Karlı, R., Alacam, H., Unal, R., Kucuk, H., Aksoy, A., Ayhan, E. (2013). Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian Journal of Otolaryngology and Head ve Neck Surgery, 65(4), 350-353.
  • Kilciler, G., Genc, H., Tapan, S., Ors, F., Kara, M., Karadurmus, N., . . . Bagci, S. (2010). Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease. Upsala journal of medical sciences, 115(4), 253-259.
  • Kılıçlı-Çamur, N., Kılıçlı-Çamur, N., Konuralp, C., Eskiser, A. (2005). Could mean platelet volume be a predictive marker for acute myocardial infarction? Medical science monitor, 11(8), CR387-CR392.
  • Kılınçalp, S., Çoban, Ş., Akıncı, H., Hamamcı, M., Karaahmet, F., Coşkun, Y., . . . Yüksel, İ. (2015). Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. European Journal of Cancer Prevention, 24(4), 328-333.
  • Kum, R. O., Özcan, M., Baklacı, D., Kum, N. Y., Yılmaz, Y. F., Ünal, A., . . . Avcı, Y. (2015). Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss. Brazilian journal of otorhinolaryngology, 81(6), 636-641.
  • Kuyumcu, M. E., Yeşil, Y., Öztürk, Z. A., Kızılarslanoğlu, C., Etgül, S., Halil, M., . . . Arıoğul, S. (2012). The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dementia and geriatric cognitive disorders, 34(2), 69-74.
  • Machin, S., Briggs, C. (2010). Mean platelet volume: a quick, easy determinant of thrombotic risk? Journal of Thrombosis and Haemostasis, 8(1), 146-147.
  • Martin, J., Shaw, T., Heggie, J., Penington, D. (1983). Measurement of the density of human platelets and its relationship to volume. British journal of haematology, 54(3), 337-352.
  • Masuda, M., Kanzaki, S., Minami, S., Kikuchi, J., Kanzaki, J., Sato, H., . . . Ogawa, K. (2012). Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otology ve Neurotology, 33(7), 1142-1150.
  • Mosnier, I., Stepanian, A., Baron, G., Bodenez, C., Robier, A., Meyer, B., . . . Ameziane, N. (2011). Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiology and Neurotology, 16(1), 55-66.
  • Özkan, B., Uysal, O. K., Duran, M., Şahin, D. Y., Elbasan, Z., Tekin, K., . . . Caylı, M. (2013). Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction. Angiology, 64(5), 371-374.
  • Papa, A., Emdin, M., Passino, C., Michelassi, C., Battaglia, D., Cocci, F. (2008). Predictive value of elevated neutrophil–lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clinica chimica acta, 395(1-2), 27-31.
  • Rudack, C., Langer, C., Stoll, W., Rust, S., Walter, M. (2006). Vascular risk factors in sudden hearing loss. Thrombosis and haemostasis, 95(03), 454-461.
  • Seo, Y. J., Choi, J. Y., Moon, I. S. (2014). Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Disease markers, 2014, 1-6.
  • Shikowitz, M. J. (1991). Sudden sensorineural hearing loss. The Medical Clinics of North America, 75(6), 1239-1250.
  • Siegel, L. (1975). The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am, 8(2), 467.
  • Son, E. J., Bang, J. H., Kang, J. G. (2007). Anterior inferior cerebellar artery infarction presenting with sudden hearing loss and vertigo. The Laryngoscope, 117(3), 556-558.
  • Stachler, R. J., Chandrasekhar, S. S., Archer, S. M., Rosenfeld, R. M., Schwartz, S. R., Barrs, D. M., . . . Ganiats, T. G. (2012). Clinical practice guideline: sudden hearing loss. Otolaryngology-Head and Neck Surgery, 146(3), S1-S35.
  • Tokgöz, S., Kayrak, M., Akpınar, Z., Seyithanoğlu, A., Güney, F., Yürüten, B. (2013). Neutrophil lymphocyte ratio as a predictor of stroke. Journal of Stroke and Cerebrovascular Diseases, 22(7), 1169-1174.
  • Ulu, S., Ulu, M. S., Ahsen, A., Yücedağ, F., Ayçiçek, A., Çelik, S. (2013). Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss. European Archives of Oto-Rhino-Laryngology, 270(11), 2875-2878.
  • Ulu, S., Ulu, M. S., Bucak, A., Ahsen, A., Yücedağ, F., Ayçiçek, A. (2013). Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otology ve Neurotology, 34(8), 1400-1404.
  • Weng, S. F., Chen, Y. S., Liu, T. C., Hsu, C. J., Tseng, F. Y. (2004). Prognostic factors of sudden sensorineural hearing loss in diabetic patients. Diabetes Care, 27(10), 2560-2561.
  • Wilson, W. R., Byl, F. M., Laird, N. (1980). The efficacy of steroids in the treatment of idiopathic sudden hearing loss: a double-blind clinical study. Archives of otolaryngology, 106(12), 772-776.

Effect of Inflammatory Markers in Routine Hemogram on Prognosis in Patients with Sudden Hearing Loss

Yıl 2021, Cilt: 9 Sayı: 1, 130 - 139, 25.03.2021

Mehmet Tan Deniz Uğur Cengiz Oguz Karakaş Tuba Bayindir

https://doi.org/10.33715/inonusaglik.847420
Cited By: 1

Öz

This study evaluates the effect of hemogram results on the degree and prognosis of patients with sudden hearing loss (SHL). 70 of 325 patients diagnosed with SHL in our clinic between 2015-2020 were included in the study. Routine hemogram parameters and hearing tests of the patients before treatment were examined. A control group was formed from healthy individuals with similar characteristics. The patients were divided into 3 groups according to the degree of hearing loss. In our study, hemoglobin, mean platelet volume (MPV), platelet, neutrophil, neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), platelet x neutrophil / lymphocyte (PxN/L) values were compared. Statistical difference was found between the group with SHL and the control group in terms of hemoglobin, neutrophil, lymphocyte, MPV, PLO, NLO, PxN/L values. These parameters can be used as a new marker in the diagnosis and prognosis of SHL with a routine and inexpensive test performed at the diagnosis stage of the disease.

Anahtar Kelimeler

Sudden hearing loss hemogram platelet

Kaynakça

  • Akopuz, A., Turan, V., Özcan, A., Kopuz, Y., Toz, E., Kurt, S. (2016). A novel marker for the assessment of the treatment result in pelvic inflammatory disease. Minerva ginecologica, 68(2), 117-123.
  • Balta, S., Demirkol, S., Küçük, U. (2013). The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice. Hemodialysis International, 4(17), 668-669.
  • Boyraz, İ., Koç, B., Boyacı, A., Tutoğlu, A., Sarman, H., Özkan, H. (2014). Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. International journal of clinical and experimental medicine, 7(9), 2912.
  • Braekkan, S., Mathiesen, E., Njølstad, I., Wilsgaard, T., Størmer, J., Hansen, J. (2010). Mean platelet volume is a risk factor for venous thromboembolism: the Tromsø study. Journal of Thrombosis and Haemostasis, 8(1), 157-162.
  • Cadoni, G., Agostino, S., Manna, R., De Santis, A., Fetoni, A. R., Vulpiani, P., . . . Ottaviani, F. (2003). Clinical associations of serum antiendothelial cell antibodies in patients with sudden sensorineural hearing loss. The Laryngoscope, 113(5), 797-801.
  • Caligiuri, G., Nicoletti, A. (2006). Lymphocyte responses in acute coronary syndromes: lack of regulation spawns deviant behaviour. In: The University of Chicago Press.
  • Chau, J. K., Lin, J. R., Atashband, S., Irvine, R. A., Westerberg, B. D. (2010). Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss. The Laryngoscope, 120(5), 1011-1021.
  • Chu, S., Becker, R., Berger, P., Bhatt, D., Eikelboom, J., Konkle, B., . . . Berger, J. (2010). Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta‐analysis. Journal of Thrombosis and Haemostasis, 8(1), 148-156.
  • Cook, E. J., Walsh, S. R., Farooq, N., Alberts, J. C., Justin, T. A., Keeling, N. J. (2007). Post-operative neutrophil–lymphocyte ratio predicts complications following colorectal surgery. International Journal of Surgery, 5(1), 27-30.
  • Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., . . . Maguire, P. B. (2004). Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Blood, 103(6), 2096-2104.
  • Durmuş, K., Terzi, H., Karataş, T. D., Doğan, M., Uysal, I. Ö., Sencan, M., . . . Altuntaş, E. E. (2016). Assessment of hematological factors involved in development and prognosis of idiopathic sudden sensorineural hearing loss. Journal of Craniofacial Surgery, 27(1), e85-e91.
  • Gary, T., Pichler, M., Belaj, K., Hafner, F., Gerger, A., Froehlich, H., . . . Pilger, E. (2013). Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PloS one, 8(7), e67688.
  • Hiramatsu, M., Teranishi, M., Uchida, Y., Nishio, N., Suzuki, H., Kato, K., . . . Suzuki, H. (2012). Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. Journal of Neurogenetics, 26(3-4), 387-396.
  • Imtiaz, F., Shafique, K., Mirza, S. S., Ayoob, Z., Vart, P., Rao, S. (2012). Neutrophil lymphocyte ratio as a measure of systemic inflammation in prevalent chronic diseases in Asian population. International archives of medicine, 5(2), 1-6.
  • Kallinen, J., Laippala, P., Laurikainen, E., Grénman, R. (1997). Sudden deafness: a comparison of anticoagulant therapy and carbogen inhalation therapy. Annals of Otology, Rhinology ve Laryngology, 106(1), 22-26.
  • Karlı, R., Alacam, H., Unal, R., Kucuk, H., Aksoy, A., Ayhan, E. (2013). Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss? Indian Journal of Otolaryngology and Head ve Neck Surgery, 65(4), 350-353.
  • Kilciler, G., Genc, H., Tapan, S., Ors, F., Kara, M., Karadurmus, N., . . . Bagci, S. (2010). Mean platelet volume and its relationship with carotid atherosclerosis in subjects with non-alcoholic fatty liver disease. Upsala journal of medical sciences, 115(4), 253-259.
  • Kılıçlı-Çamur, N., Kılıçlı-Çamur, N., Konuralp, C., Eskiser, A. (2005). Could mean platelet volume be a predictive marker for acute myocardial infarction? Medical science monitor, 11(8), CR387-CR392.
  • Kılınçalp, S., Çoban, Ş., Akıncı, H., Hamamcı, M., Karaahmet, F., Coşkun, Y., . . . Yüksel, İ. (2015). Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and mean platelet volume as potential biomarkers for early detection and monitoring of colorectal adenocarcinoma. European Journal of Cancer Prevention, 24(4), 328-333.
  • Kum, R. O., Özcan, M., Baklacı, D., Kum, N. Y., Yılmaz, Y. F., Ünal, A., . . . Avcı, Y. (2015). Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss. Brazilian journal of otorhinolaryngology, 81(6), 636-641.
  • Kuyumcu, M. E., Yeşil, Y., Öztürk, Z. A., Kızılarslanoğlu, C., Etgül, S., Halil, M., . . . Arıoğul, S. (2012). The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dementia and geriatric cognitive disorders, 34(2), 69-74.
  • Machin, S., Briggs, C. (2010). Mean platelet volume: a quick, easy determinant of thrombotic risk? Journal of Thrombosis and Haemostasis, 8(1), 146-147.
  • Martin, J., Shaw, T., Heggie, J., Penington, D. (1983). Measurement of the density of human platelets and its relationship to volume. British journal of haematology, 54(3), 337-352.
  • Masuda, M., Kanzaki, S., Minami, S., Kikuchi, J., Kanzaki, J., Sato, H., . . . Ogawa, K. (2012). Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otology ve Neurotology, 33(7), 1142-1150.
  • Mosnier, I., Stepanian, A., Baron, G., Bodenez, C., Robier, A., Meyer, B., . . . Ameziane, N. (2011). Cardiovascular and thromboembolic risk factors in idiopathic sudden sensorineural hearing loss: a case-control study. Audiology and Neurotology, 16(1), 55-66.
  • Özkan, B., Uysal, O. K., Duran, M., Şahin, D. Y., Elbasan, Z., Tekin, K., . . . Caylı, M. (2013). Relationship between mean platelet volume and atherosclerosis in young patients with ST elevation myocardial infarction. Angiology, 64(5), 371-374.
  • Papa, A., Emdin, M., Passino, C., Michelassi, C., Battaglia, D., Cocci, F. (2008). Predictive value of elevated neutrophil–lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease. Clinica chimica acta, 395(1-2), 27-31.
  • Rudack, C., Langer, C., Stoll, W., Rust, S., Walter, M. (2006). Vascular risk factors in sudden hearing loss. Thrombosis and haemostasis, 95(03), 454-461.
  • Seo, Y. J., Choi, J. Y., Moon, I. S. (2014). Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Disease markers, 2014, 1-6.
  • Shikowitz, M. J. (1991). Sudden sensorineural hearing loss. The Medical Clinics of North America, 75(6), 1239-1250.
  • Siegel, L. (1975). The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am, 8(2), 467.
  • Son, E. J., Bang, J. H., Kang, J. G. (2007). Anterior inferior cerebellar artery infarction presenting with sudden hearing loss and vertigo. The Laryngoscope, 117(3), 556-558.
  • Stachler, R. J., Chandrasekhar, S. S., Archer, S. M., Rosenfeld, R. M., Schwartz, S. R., Barrs, D. M., . . . Ganiats, T. G. (2012). Clinical practice guideline: sudden hearing loss. Otolaryngology-Head and Neck Surgery, 146(3), S1-S35.
  • Tokgöz, S., Kayrak, M., Akpınar, Z., Seyithanoğlu, A., Güney, F., Yürüten, B. (2013). Neutrophil lymphocyte ratio as a predictor of stroke. Journal of Stroke and Cerebrovascular Diseases, 22(7), 1169-1174.
  • Ulu, S., Ulu, M. S., Ahsen, A., Yücedağ, F., Ayçiçek, A., Çelik, S. (2013). Increased levels of mean platelet volume: a possible relationship with idiopathic sudden hearing loss. European Archives of Oto-Rhino-Laryngology, 270(11), 2875-2878.
  • Ulu, S., Ulu, M. S., Bucak, A., Ahsen, A., Yücedağ, F., Ayçiçek, A. (2013). Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otology ve Neurotology, 34(8), 1400-1404.
  • Weng, S. F., Chen, Y. S., Liu, T. C., Hsu, C. J., Tseng, F. Y. (2004). Prognostic factors of sudden sensorineural hearing loss in diabetic patients. Diabetes Care, 27(10), 2560-2561.
  • Wilson, W. R., Byl, F. M., Laird, N. (1980). The efficacy of steroids in the treatment of idiopathic sudden hearing loss: a double-blind clinical study. Archives of otolaryngology, 106(12), 772-776.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makalesi
Yazarlar

Mehmet Tan 0000-0001-8557-0886

Deniz Uğur Cengiz 0000-0002-7855-0251

Oguz Karakaş 0000-0002-5558-1303

Tuba Bayindir 0000-0003-4150-5016

Yayımlanma Tarihi 25 Mart 2021
Gönderilme Tarihi 26 Aralık 2020
Kabul Tarihi 8 Şubat 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 9 Sayı: 1

Kaynak Göster

APA Tan, M., Cengiz, D. U., Karakaş, O., Bayindir, T. (2021). ANİ İŞİTME KAYIPLI HASTALARDA RUTİN HEMOGRAM İÇİNDEKİ İNFLAMATUAR MARKIRLARIN PROGNOZA ETKİSİ. İnönü Üniversitesi Sağlık Hizmetleri Meslek Yüksek Okulu Dergisi, 9(1), 130-139. https://doi.org/10.33715/inonusaglik.847420

Cited By

Ani İşitme Kaybında C-Reaktif Protein Albümin Oranı ve Hematolojik Parametrelerin Prognostik Değeri
Phoenix Medical Journal
https://doi.org/10.38175/phnx.1239411
 Kapak Resmi İndir

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