Purpose - The purpose of this study is to examine the effect of wellness tourism participants’ self-efficacy and stress on flow and satisfaction. Design, data, and methodology -Based on extensive literature, this study chose stress and self-efficacy (physical, social-emotional, and cognitive) as main factors resulted from the experience of wellness tourism program. Data were collected from the participants of wellness tourism program operated in Jecheon and Chungju city, South Korea from February 24 to March 8, 2021. A total of 193 samples were used for hypotheses test by using regression analysis Result- As findings, the perceived level of stress exerted a significant impact on flow, and only social-emotional factor as self-efficacy showed a significant effect on flow. Interestingly, while stress had a significant effect on satisfaction, none of self-efficacy factors showed a significant effect on satisfaction. Conclusions - This study informed that the higher the level of stress awareness, the harder it is to focus on the wellness tourism program. In addition, the study suggested to increase more social activities to enhance participants’ active involvement in wellness program.