« Back to Farmacia Journal 5/2022

CURCUMIN CO-LOADED WITH A LIPID MEDIATOR IN THE SAME NANOSTRUCTURED LIPID DELIVERY SYSTEM

LUCIA MARINA CRISTINA COC 1, IOANA LACATUSU 2*, NICOLETA BADEA 3, OVIDIU PENES 4, CALIN P. COBELSCHI 5, ANCA POP 6, AURELIA MEGHEA 1

1Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 1 Polizu Street, 011061, Bucharest, Romania
2Department of Organic Chemistry, University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 1 Polizu Street, 011061, Bucharest, Romania
3Department of General Chemistry, University Politehnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 1 Polizu Street, 011061, Bucharest, Romania
4Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 030167, Bucharest, Romania 5Faculty of Medicine, Transilvania University, 500019, Brașov, Romania 6

Download Full Article PDF

This study focuses on comparing the ability of two kinds of lipid matrices – solid lipids and vegetable oil associated or not with a lipid mediator (phenylalaninol oleamide, PO), for an efficient loading of Curcumin (CRC) into nanostructured lipid carriers (NLC). The Curcumin-loaded NLC were analysed in terms of particle size, physical stability, and encapsulation efficiency. By using the in vitro ABTS assay this research underlined the dominance of vegetable oils on the antioxidant properties of developed NLC formulations prepared with argan oil (AO) and linseed oil (LO). Another direction was to investigate the influence of the argan oil and linseed oil for a desired in vitro sustained release of CRC from the designed NLC formulations. Both antioxidant activity results and controlled release study highlighted the potential role of such formulation in normalizing the in vitro fate of poorly soluble Curcumin.