Chestnut honey as a complementary medicine: determination of antibacterial activity, heavy metal residue and health risk assessment

Mesut Ertan Güneş

doi:10.31797/vetbio.931144

Research Article

Kestane Balı Tıbbi Bir Baldır: Yalova Balının Antibakteriyel etkinliği, ağır metal profilive sağlık riski

Year 2021, Volume: 6 Issue: 2, 82 - 89, 31.08.2021

Mesut Ertan Güneş

https://doi.org/10.31797/vetbio.931144

Cited By: 3

Abstract

References

Altunatmaz, S.S., Tarhan, D., Aksu, F., Özsobacı, N.P, Erman, M.,Barutçu, U.M. (2018). Levels of Chromium, Copper, Iron, Magnesium, Manganese, Selenium, Zinc, Cadmium, Lead and Aluminium of honey varieties produced in Turkey. Food Science and Technology, 39:392-397. Doi :10.1590/fst.19718
Arıkan A.(2010). The effect of traffıc on heavy metal accumulatıon ın bee products. Ms Thesis, Gaziosmanpasa University,Graduate School of Natural and Applied Sciences , Tokat.
Aygün, O. (2020). Elazığ’da Üretilen Balların Bazı Toksik Ağır Metal Düzeyleri. Fırat Üniversitesi Mühendislik Bilimleri Dergisi, 32(1), 119-125.
Ayvaz,M Ç; Ömür,B; Ertürk, Ö; kabakçı, D (2018). Phenolic profiles, antioxidant, antimicr obial, and DNA damageinhibitory activities of chestnut honeys from Black Sea Regionof Turkey. Journal of Food Biochemistry 42:e12502
Bengü, A.Ş., Kutlu, M.A. (2020). Bingöl’den temin edilen ballarda ıcp-ms ile bazı temel ve toksik elementlerin analizi. Uludağ Arıcılık Dergisi, 20 (1): 1-12.
Bogdanov, S; Jurendıc, RS; Sieber, R; Gallmann, P (2008). Honey for Nutrition and Health: A Review. Journal of the American College of Nutrition, 27 (6): 677-689
Citak,D., Silici,S., Tuzen, M., Soylak, M. (2012). Determination of toxic and essential elements in sunflower honeyfrom Thrace Region, Turkey. International.Journal of Food Science and Tech, 47:107–113. doi:10.1111/j.1365-2621.2011.02814.x
Combarros-Fuertes, P , Estevinho, L.M., Teixeira-Santos, R., Rodrigues, A.G., Pina-Vaz, C., Fresno, J.M., Eugenia Tornadijo,M. (2020). Antibacterial Action Mechanisms of Honey: Physiological Effects of Avocado, Chestnut,and Polyfloral Honey upon Staphylococcus aureus and Escherichia coli. Molecules, 25, 1252. doi:10.3390/molecules25051252
Dağ,B; Sıralı,R; Tarakçı,Z (2017). Investigation Of Some Properties Of Chestnut Honey Produced In Black Sea Region Of Turkey. Batman University Journal of Life Sciences,7(2/2):118-123
De Oliveira RC, Queiroz SCDN, Da Luz CFP, Porto RS, Rath S. (2016). Bee pollen as a bioindicator of environmental pesticide contamination. Chemosphere,163:525–534 doi:10.1016/j.chemosphere.2016.08.022
Duo, D H; Dziao, S T (1937). Nachweis antibakterieller, hitze- und lichtempfindlicher Hemmungsstoffe Inhibine im Naturhonig Blatenhonig. Zeitschrift far Hygiene und lnfektionskrankheiten, 120: 155-167)
Dustmann, J H (1979). Antibacterial effect of honey. Apiacta, 14(1): 7-11.) EFSA (2012)Scientific Committee. Scientific panels and units in theabsence of actual measured data.
European Food Safety Authority Journal, 10: 2579.doi: 10.2903/j.efsa.2012.2579
FAO/WHO Expert Committee on Food Additives (JECFA) (2011). Safety evaluation of certain food additives andcontaminants. WHO Food Additives. 63: 605-685.
F.A.O. (Food and Agriculture Organization of the United Nations) (2017). Largest consumers of honey. 1–2. accessed 2020 Oct.1http://www.fao.org/3/ca4657en/ca4657en.pdf.
Güneş, M. E., Şahin, S., Demir, C., Borum, E., & Tosunoglu, A. (2017).Determination of phenolic compounds profile in chestnut and floralhoneys and their antioxidant and antimicrobial activities. Journal of Food Biochemistry, 41(3), 1–12.
Idris, Y. M. A., Mariod, A. A., Hamad, S. I. (2011).Physicochemical properties, phenolic contents and antioxidant activity of Sudanese honey. International Journal of Food Properties, 14, 450–458.
Kolayli, S., Can, Z., Yildiz, O, Sahin, H., Karaoglu, S.A. (2016). A comparative study of the antihyaluronidase, antiurease, antioxidant, antimicrobial and physicochemical properties of different unifloral degrees of chestnut (Castanea sativa Mill.) honeys. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S3): 96–104. https://doi.org/10.1080/14756366.2016.1209494
Küçük, M; Kolaylı, S; Karaoğlu,Ş; Ulus,Y,E; Baltacı,C; Candan,F (2007). Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chemistry, 100(2): 526-534 Leblebici, Z.(2006). Kayseri Yöresinde Bulunan Bazı Bal Örneklerinde Ağır Metal Kirliliğinin Belirlenmesi, Yüksek Lisans Tezi, Erciyes Üniversitesi Fen Bilimleri Enstitüsü, Kayseri, 71.
Magna, E.K., Dabi,M., Badu, E, Owusu, P (2108). Determination of Heavy Metals and Potential Health Risk Assessment of Honey Harvested from the Tamale Metropolis of Ghana Using Atomic Absorption Spectrophotometer (AAS). Elixir Pollution, 121:51522-51525
McLoone, P., Tabys,D., Fyfe, L. (2020). Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature. Clinical, Cosmetic and Investigational Dermatology,13: 875–888. doi: 10.2147/CCID.S282143.
Molan, P C; Smith, I M; Reid, G M (1988). A comparison of the antibacterial activity of some New Zealand honeys. Journal of Apicultural Research, 27(4): 252-256.
Naccari, C., Macaluso, A., Giangrosso, G., Naccari, F., Ferrantelli, V. (2014). Risk Assessment of Heavy Metals and Pesticides in Honey From Sicily (Italy). Journal of Food Research, 3(2), 107-117. doi:10.5539/jfr.v3n2p107
Nisbet, C., Guler, A., Yarim, G.F.,Cenesiz, S.,Ardalı,Y. (2013). Çevre ve flora kaynaklarının arı ürünlerinin mineral madde içerikleri ile ilişkisi. Türk Biyokimya Dergisi, 38 (4) ; 494–498.
Özbolat,G.,Tuli,A. (2016). Ağır metal toksisitesinin insan sağlığına etkileri. Archives Medical Review Journal, 25(4):502-521. doi:10.17827/aktd.253562
Perez, C., Pauli, M., & Bazerque, P. (1990). An antibiotic assay by the agar well diffusion method. Acta Biologia et Medicine Experimentalis, 15, 113–115.
Ru,Q.M., Feng, Q., He, H_J. (2013). Risk assessment of heavy metals in honey consumed in Zhejiang province, southeastern China. Food and Chemical Toxicology. 53: 256-262. https://doi.org/10.1016/j.fct.2012.12.015
Sarıkaya, A. O., Ulusoy, E., Ozturk, N., Tunçel, M., Kolayli, S. (2009).Activity and phenolic acidconstituents of chestnut (Castania sativamill.) honey and propolis. Journal of Food Biochemistry, 33, 470–481.
Seven,T., Can,B, Darende,B.N, Ocak,S. (2018), Hava ve Toprakta Ağır Metal Kirliliği. Ulusal Çevre Bilimleri Araştırma Dergisi, 1(2): 91-103
Silici,S., Uluozlu, O.Z.,Tuzen,M,Soylak,M. (2013). Honeybees and honey as monitors for heavy metal contamination near thermal power plants in Mugla,Turkey. Toxicology and Industrial Health, 32(3): 507–516. DOI: 10.1177/0748233713503393
Şireli, U.T., Çil, G.İ., Dikmen, B.Y, Filazi, A., Ülker, H.(2015). Detection of Metals in Different Honey Brands. Kafkas Universitesi Veteriner Fakültesi Dergisi, 21(6):915-918.
Tuzen ,M., Silici,S., Mendil,D., Soylak,M.(2007). Trace element levels in honeys from different regions of Turkey. Food Chemistry, 103:325–330. Doi:10.1016/j.foodchem.2006.07.053
Türk Gıda Kodeksi Bulaşanlar Yönetmeliği (2011). Resmi Gazete, 29.12.2011, Sayı: 28157 (3. Mükerrer), Ankara
USEPA. (2009). Risk-based Concentration table. Philadelphia PA. Washington DC, USA,Environmental Protection Agency
Yarsan, E. ,Karacal, F. , Ibrahim, I.G., Dikmen,B., Koksal, A., Das, Y.K. ( 2007). Contents of Some Metals in Honeys from Different Regions in Turkey. Bulletin of Environmental Contamination and Toxicology,79:255–258. DOI: 10.1007/s00128-007-9034-9
Yıldız, O., Can, A., Saral, O., Yuluğ, E., Ozturk, F., Aliyazicioglu, R.,Canpolat,S., Kolayli, S. (2013). Hepatoprotective potential of chestnut bee pollen on carbon tetrachloride-induced hepatic damages in rats. Journal of Evidence Based Complementary and Alternative Medicine, , Special Issue, Article ID 461478, 9 p. http://dx.doi.org/10.1155/2013/461478
Yücel, Y., Sultanoğlu, P. (2013). Characterization of Hatay honeys according to their multi-element analysis using ICP-OES combined with chemometrics. Food Chemistry, 140: 231-237. . https://doi.org/10.1016/j.foodchem.2013.02.046

Chestnut honey as a complementary medicine: determination of antibacterial activity, heavy metal residue and health risk assessment

Year 2021, Volume: 6 Issue: 2, 82 - 89, 31.08.2021

Mesut Ertan Güneş

https://doi.org/10.31797/vetbio.931144

Cited By: 3

Abstract

In this study, residue levels for heavy metal content and antimicrobial effects of 30 chestnut honey samples obtained from member beekeepers of Yalova Bee Association are examined. After 30 honey samples are digested under high temperature and pressure in a microwave oven, their Arsenic (As), Lead (Pb), Cadmium (Cd), Mercury (Hg) limits are determined by using ICP-OES. By using Agar gel diffusion method, 19 of the honey samples’ antibacterial activity is tested on strains of Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), E. coli O 157: H7, B.cereus (ATCC 6633), S.typhimirium (NCTC 12416) and L.monocytogenes (ATCC 7644). Arsenic, Lead, Cadmium and Mercury residue levels in all honey samples are determined to be below the designated limits by Turkish Food Codex Regulation (2011). The non-carcinogenic health risk associated with heavy metal contamination in honey is found to be very low. None of the 19 honey samples show antibacterial effect on strains of L.monocytogenes. However, at 100% honey concentration, in all 19 honey samples antibacterial effect is observed on strains of S.typhimirium, E. coli O 157: H7, except for only one honey sample; Escherichia coli and B cereus. The antibacterial activity on these bacteria is recorded to be maintained at 50% honey concentration. At 25% honey concentration, the antibacterial effect show a decline in most of the honey samples.

Keywords

Chestnut honey, antibacterial effect, heavy metals, health risk

References

Altunatmaz, S.S., Tarhan, D., Aksu, F., Özsobacı, N.P, Erman, M.,Barutçu, U.M. (2018). Levels of Chromium, Copper, Iron, Magnesium, Manganese, Selenium, Zinc, Cadmium, Lead and Aluminium of honey varieties produced in Turkey. Food Science and Technology, 39:392-397. Doi :10.1590/fst.19718
Arıkan A.(2010). The effect of traffıc on heavy metal accumulatıon ın bee products. Ms Thesis, Gaziosmanpasa University,Graduate School of Natural and Applied Sciences , Tokat.
Aygün, O. (2020). Elazığ’da Üretilen Balların Bazı Toksik Ağır Metal Düzeyleri. Fırat Üniversitesi Mühendislik Bilimleri Dergisi, 32(1), 119-125.
Ayvaz,M Ç; Ömür,B; Ertürk, Ö; kabakçı, D (2018). Phenolic profiles, antioxidant, antimicr obial, and DNA damageinhibitory activities of chestnut honeys from Black Sea Regionof Turkey. Journal of Food Biochemistry 42:e12502
Bengü, A.Ş., Kutlu, M.A. (2020). Bingöl’den temin edilen ballarda ıcp-ms ile bazı temel ve toksik elementlerin analizi. Uludağ Arıcılık Dergisi, 20 (1): 1-12.
Bogdanov, S; Jurendıc, RS; Sieber, R; Gallmann, P (2008). Honey for Nutrition and Health: A Review. Journal of the American College of Nutrition, 27 (6): 677-689
Citak,D., Silici,S., Tuzen, M., Soylak, M. (2012). Determination of toxic and essential elements in sunflower honeyfrom Thrace Region, Turkey. International.Journal of Food Science and Tech, 47:107–113. doi:10.1111/j.1365-2621.2011.02814.x
Combarros-Fuertes, P , Estevinho, L.M., Teixeira-Santos, R., Rodrigues, A.G., Pina-Vaz, C., Fresno, J.M., Eugenia Tornadijo,M. (2020). Antibacterial Action Mechanisms of Honey: Physiological Effects of Avocado, Chestnut,and Polyfloral Honey upon Staphylococcus aureus and Escherichia coli. Molecules, 25, 1252. doi:10.3390/molecules25051252
Dağ,B; Sıralı,R; Tarakçı,Z (2017). Investigation Of Some Properties Of Chestnut Honey Produced In Black Sea Region Of Turkey. Batman University Journal of Life Sciences,7(2/2):118-123
De Oliveira RC, Queiroz SCDN, Da Luz CFP, Porto RS, Rath S. (2016). Bee pollen as a bioindicator of environmental pesticide contamination. Chemosphere,163:525–534 doi:10.1016/j.chemosphere.2016.08.022
Duo, D H; Dziao, S T (1937). Nachweis antibakterieller, hitze- und lichtempfindlicher Hemmungsstoffe Inhibine im Naturhonig Blatenhonig. Zeitschrift far Hygiene und lnfektionskrankheiten, 120: 155-167)
Dustmann, J H (1979). Antibacterial effect of honey. Apiacta, 14(1): 7-11.) EFSA (2012)Scientific Committee. Scientific panels and units in theabsence of actual measured data.
European Food Safety Authority Journal, 10: 2579.doi: 10.2903/j.efsa.2012.2579
FAO/WHO Expert Committee on Food Additives (JECFA) (2011). Safety evaluation of certain food additives andcontaminants. WHO Food Additives. 63: 605-685.
F.A.O. (Food and Agriculture Organization of the United Nations) (2017). Largest consumers of honey. 1–2. accessed 2020 Oct.1http://www.fao.org/3/ca4657en/ca4657en.pdf.
Güneş, M. E., Şahin, S., Demir, C., Borum, E., & Tosunoglu, A. (2017).Determination of phenolic compounds profile in chestnut and floralhoneys and their antioxidant and antimicrobial activities. Journal of Food Biochemistry, 41(3), 1–12.
Idris, Y. M. A., Mariod, A. A., Hamad, S. I. (2011).Physicochemical properties, phenolic contents and antioxidant activity of Sudanese honey. International Journal of Food Properties, 14, 450–458.
Kolayli, S., Can, Z., Yildiz, O, Sahin, H., Karaoglu, S.A. (2016). A comparative study of the antihyaluronidase, antiurease, antioxidant, antimicrobial and physicochemical properties of different unifloral degrees of chestnut (Castanea sativa Mill.) honeys. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S3): 96–104. https://doi.org/10.1080/14756366.2016.1209494
Küçük, M; Kolaylı, S; Karaoğlu,Ş; Ulus,Y,E; Baltacı,C; Candan,F (2007). Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chemistry, 100(2): 526-534 Leblebici, Z.(2006). Kayseri Yöresinde Bulunan Bazı Bal Örneklerinde Ağır Metal Kirliliğinin Belirlenmesi, Yüksek Lisans Tezi, Erciyes Üniversitesi Fen Bilimleri Enstitüsü, Kayseri, 71.
Magna, E.K., Dabi,M., Badu, E, Owusu, P (2108). Determination of Heavy Metals and Potential Health Risk Assessment of Honey Harvested from the Tamale Metropolis of Ghana Using Atomic Absorption Spectrophotometer (AAS). Elixir Pollution, 121:51522-51525
McLoone, P., Tabys,D., Fyfe, L. (2020). Honey Combination Therapies for Skin and Wound Infections: A Systematic Review of the Literature. Clinical, Cosmetic and Investigational Dermatology,13: 875–888. doi: 10.2147/CCID.S282143.
Molan, P C; Smith, I M; Reid, G M (1988). A comparison of the antibacterial activity of some New Zealand honeys. Journal of Apicultural Research, 27(4): 252-256.
Naccari, C., Macaluso, A., Giangrosso, G., Naccari, F., Ferrantelli, V. (2014). Risk Assessment of Heavy Metals and Pesticides in Honey From Sicily (Italy). Journal of Food Research, 3(2), 107-117. doi:10.5539/jfr.v3n2p107
Nisbet, C., Guler, A., Yarim, G.F.,Cenesiz, S.,Ardalı,Y. (2013). Çevre ve flora kaynaklarının arı ürünlerinin mineral madde içerikleri ile ilişkisi. Türk Biyokimya Dergisi, 38 (4) ; 494–498.
Özbolat,G.,Tuli,A. (2016). Ağır metal toksisitesinin insan sağlığına etkileri. Archives Medical Review Journal, 25(4):502-521. doi:10.17827/aktd.253562
Perez, C., Pauli, M., & Bazerque, P. (1990). An antibiotic assay by the agar well diffusion method. Acta Biologia et Medicine Experimentalis, 15, 113–115.
Ru,Q.M., Feng, Q., He, H_J. (2013). Risk assessment of heavy metals in honey consumed in Zhejiang province, southeastern China. Food and Chemical Toxicology. 53: 256-262. https://doi.org/10.1016/j.fct.2012.12.015
Sarıkaya, A. O., Ulusoy, E., Ozturk, N., Tunçel, M., Kolayli, S. (2009).Activity and phenolic acidconstituents of chestnut (Castania sativamill.) honey and propolis. Journal of Food Biochemistry, 33, 470–481.
Seven,T., Can,B, Darende,B.N, Ocak,S. (2018), Hava ve Toprakta Ağır Metal Kirliliği. Ulusal Çevre Bilimleri Araştırma Dergisi, 1(2): 91-103
Silici,S., Uluozlu, O.Z.,Tuzen,M,Soylak,M. (2013). Honeybees and honey as monitors for heavy metal contamination near thermal power plants in Mugla,Turkey. Toxicology and Industrial Health, 32(3): 507–516. DOI: 10.1177/0748233713503393
Şireli, U.T., Çil, G.İ., Dikmen, B.Y, Filazi, A., Ülker, H.(2015). Detection of Metals in Different Honey Brands. Kafkas Universitesi Veteriner Fakültesi Dergisi, 21(6):915-918.
Tuzen ,M., Silici,S., Mendil,D., Soylak,M.(2007). Trace element levels in honeys from different regions of Turkey. Food Chemistry, 103:325–330. Doi:10.1016/j.foodchem.2006.07.053
Türk Gıda Kodeksi Bulaşanlar Yönetmeliği (2011). Resmi Gazete, 29.12.2011, Sayı: 28157 (3. Mükerrer), Ankara
USEPA. (2009). Risk-based Concentration table. Philadelphia PA. Washington DC, USA,Environmental Protection Agency
Yarsan, E. ,Karacal, F. , Ibrahim, I.G., Dikmen,B., Koksal, A., Das, Y.K. ( 2007). Contents of Some Metals in Honeys from Different Regions in Turkey. Bulletin of Environmental Contamination and Toxicology,79:255–258. DOI: 10.1007/s00128-007-9034-9
Yıldız, O., Can, A., Saral, O., Yuluğ, E., Ozturk, F., Aliyazicioglu, R.,Canpolat,S., Kolayli, S. (2013). Hepatoprotective potential of chestnut bee pollen on carbon tetrachloride-induced hepatic damages in rats. Journal of Evidence Based Complementary and Alternative Medicine, , Special Issue, Article ID 461478, 9 p. http://dx.doi.org/10.1155/2013/461478
Yücel, Y., Sultanoğlu, P. (2013). Characterization of Hatay honeys according to their multi-element analysis using ICP-OES combined with chemometrics. Food Chemistry, 140: 231-237. . https://doi.org/10.1016/j.foodchem.2013.02.046

There are 37 citations in total.

Details

Primary Language	English
Subjects	Veterinary Sciences, Veterinary Surgery
Journal Section	Research Articles
Authors	Mesut Ertan Güneş 0000-0002-9347-8307
Publication Date	August 31, 2021
Submission Date	May 1, 2021
Acceptance Date	July 28, 2021
Published in Issue	Year 2021 Volume: 6 Issue: 2

Cite

APA	Güneş, M. E. (2021). Chestnut honey as a complementary medicine: determination of antibacterial activity, heavy metal residue and health risk assessment. Journal of Advances in VetBio Science and Techniques, 6(2), 82-89. https://doi.org/10.31797/vetbio.931144