Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity

Hiroshi KURIHARA; Hiroshi SHIBATA; Nobuo TSURUOKA; Yoshinobu KISO; Keiich ABE; Hajime NAGAI; Harukazu FUKAMI

doi:10.3136/fstr.15.179

Notes

Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity

Hiroshi KURIHARA, Hiroshi SHIBATA, Nobuo TSURUOKA, Yoshinobu KISO, Keiich ABE, Hajime NAGAI, Harukazu FUKAMI

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Keywords: carnosine, oxygen radical absorbance capacity (ORAC), glutathione, ascorbic acid, restraint-stress

JOURNAL FREE ACCESS

2009 Volume 15 Issue 2 Pages 179-184

DOI https://doi.org/10.3136/fstr.15.179

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Abstract

Oral administration of carnosine (β-alanyl-L-histidine) in mice treated with restraint stress moderately alleviated a stress-induced decrease in plasma oxygen radical absorbance capacity (ORAC) activity (P = 0.075). Carnosine treatment also increased the level of plasma glutathione (GSH) and ascorbic acid compared with those in the restraint stress mice. Carnosine and related compounds anserine, histidine and histamine exhibited ORAC activity in vitro, while β-alanine was not effective. These results suggest that carnosine exerts a protective effect against the stress-induced elevation of the oxidative level in plasma.

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