Abstract
The bioinformatic search of the plant homologues of human protein kinases SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK2, and PASK, involved in the phosphorylation of microtubular proteins and regulation of cell division, was carried out. The plant homologues of protein kinases SLK, MAST2, and AURKA were identified. It was found that the closest homologue of human protein kinase AURKA is a protein A7PY12_VITVI (STALK, Serine-Threonine Aurora-Like Kinase) from grapes (Vitis vinifera), whose function is still unknown. The reconstruction and analysis of the 3D-structure of the STALK protein confirmed its relation to the group of AURKA-like protein kinases.
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Original Russian Text © P.A. Karpov, E.S. Nadezhdina, A.I. Emets, V.G. Matusov, A.Yu. Nyporko, N.Yu. Shashina, Ya.B. Blume, 2009, published in Tsitologiya i Genetika, 2009, Vol. 43, No. 3, pp. 63–79.
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Karpov, P.A., Nadezhdina, E.S., Emets, A.I. et al. Bioinformatic search of plant protein kinases involved in the phosphorylation of microtubular proteins and the regulation of the cell cycle. Cytol. Genet. 43, 201–215 (2009). https://doi.org/10.3103/S0095452709030104
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DOI: https://doi.org/10.3103/S0095452709030104