Abstract
We analyzed the sensitivity of a separationless immunoassay scheme using functionalized magnetic nanoparticles (MNPs) and a sensitive HTS SQUID magnetometer. The signal of a 100 μL sample at a concentration of 1 mg/mL and field of 7.5 nT was 20 mΦ0. This makes it possible for the sensitivity to be within the range of 50 ng/mL at the required time of up to 100 s per a point in the frequency spectrum.
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References
V. A. Spiridonova, Biochem. (Moscow) Suppl. Ser. B: Biomed. Chem. 4, 138 (2010).
C. Tuerk and L. Gold, Science 249, 505 (1990).
K. Enpuku, T. Minotani, M. Hotta, and A. Nakahodo, IEEE Trans. Appl. Supercond. 11, 661 (2001).
P. Astalan, F. Ahrentorp, C. Johansson, K. Larsson, and A. Krozer, Biosens. Bioelectron. 19, 945 (2004).
K. Tsukamoto, D. Saitoh, N. Suzuki, et al., IEEE Trans. Appl. Supercond. 15, 656 (2005).
F. Oisjoen, P. Magnelind, A. Kalabukhov, and D. Winkler, Supercond. Sci. Technol. 21, 034004 (2008).
M. Chukharkin, A. Kalabukhov, J. F. Schneiderman, et al., Appl. Phys. Lett. 101, 042602 (2012).
M. B. Ketchen, J. Appl. Phys. 58, 1 (1985).
C. Carr, A. Eulenburg, E. Romans, et al., IEEE Trans. Appl. Supercond. 9, 3105 (2002).
P. A. Rosenthal, M. R. Beasley, K. Char, M. S. Colclough, and G. Zaharchuk, Appl. Phys. Lett. 59, 3482 (1991).
P. Seidel, F. Schrey, L. Dorrer, et al., Supercond. Sci. Technol. 15, 150 (2002).
F. Oisjoen, J. F. Schneiderman, M. Zaborowska, et al., IEEE Trans. Appl. Supercond. 19, 848 (2009).
https://www.acreo.se.
V. K. Kornev, I. I. Soloviev, N. V. Klenov, and N. V. Kolotinskiy, IEEE Trans. Appl. Supercond. 26, 1601205 (2016).
V. K. Kornev, I. I. Soloviev, N. V. Klenov, and O. A. Mukhanov, Supercond. Sci. Technol. 20, S362 (2007).
V. K. Kornev, I. I. Soloviev, N. V. Klenov, et al., IEEE Trans. Appl. Supercond. 21, 713 (2011).
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Original Russian Text © O.V. Snigirev, I.I. Soloviev, A.S. Kalabukhov, M.L. Chukharkin, 2017, published in Vestnik Moskovskogo Universiteta, Seriya 3: Fizika, Astronomiya, 2017, No. 1, pp. 94–99.
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Snigirev, O.V., Soloviev, I.I., Kalabukhov, A.S. et al. Observation of Brownian relaxation of magnetic nanoparticles using HTS SQUID. Moscow Univ. Phys. 72, 95–100 (2017). https://doi.org/10.3103/S0027134917010143
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DOI: https://doi.org/10.3103/S0027134917010143