Abstract
The objective of the survey is to reveal the effects of a dysfunctional relationship between the gonadal steroids (progesterone and 17β-estradiol) on occurrence of inflammatory diseases (endometriosis and metritis-mastitis-agalactia) in sows in the postpartum period. The surveys were carried out with 27 sows at 106–107 days of gestation, measuring the concentrations of progesterone and 17β-estradiol on the seventh, fifth, third, and first days before the expected farrowing date and during parturition. The subsequent retrospective analysis of the results of the collected measurements was performed depending on the course of the postpartum period in sows. It was ascertained that the progesterone blood concentrations the 3 days before the farrowing date and during parturition in sows affected with postpartum diseases were higher by 48.7 (p < 0.01) and 31.1% (p < 0.05), respectively, than that in the animals that remained healthy after farrowing, while the estradiol concentrations were lower by 10.1 and 21.0%, respectively. In addition, progesterone-to-estradiol ratio variables were 1.6-fold (p < 0.01) and 1.7-fold (p < 0.01) higher, respectively. This allows for the consideration that a dysfunctional relationship between the hormones in sows at the end of gestation and during parturition can be one of the factors causing the pathological processes of an inflammatory type in the postpartum period. In addition, it is eligible to apply the progesterone-to-estradiol ratio as a criterion for predicting the risk for disease incidence.
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REFERENCES
Kotsarev, V.N., Shumskii, N.I., Nezhdanov, A.G., and Boev, V.Yu., On the etiology, diagnosis, prevention, and therapy of postpartum purulent-inflammatory diseases of genital organs in sows, Vestn. Voronezh. Gos. Agrarn. Univ., 2014, no. 4, pp. 225–229.
Arzhanikov, A.V., Veterinary and sanitary support for sows in commercial farming, Sovremennye innovatsionnye podkhody v reshenii aktual’nykh veterinarnykh problem v zhivotnovodstve: Materialy Mezhdunarodnoi nauchno-prakticheskoi konferentsii (Current Innovative Approaches to Solving Urgent Veterinary Problems in Animal Husbandry: Proc. Int. Sci.-Pract. Conf.), Omsk, 2017, pp. 47–52.
Kashkovskaya, L.M., Safonova, M.I., Balyshev, A.V., and Abramov, S.V., MMA syndrome: A modern approach to complex therapy, Svinovodstvo, 2018, no. 1, pp. 66–68.
Orobets, V.A. and Kashkovskaya, L.M., Prevention of postpartum pathologies in sows, Veterinariya, 2018, no. 6, pp. 10–14.
Khlopitskii, V.P. and Kriventsev, K.A., The spread of postpartum diseases in sows and their importance in the reproductive system, Veterinariya, 2014, no. 5, pp. 38–41.
The role of cytokines in the regulation of the inflammatory response. http://helpiks.org/1-83705.html.
Simbirtsev, A.S., Cytokines—a new system for regulating body’s defensive responses, Research Institute for Extra Pure Biological Products, St. Petersburg. http://betaleukin.ru/lib/24/26.
Cytokines—Classification, Role in the Body, and treatment (Cytokine Therapy). http://www.tiensmed.ru/ news/citokiny-ab1.html.
Saji, F., Samejima, Y., and Kamiura, S., Cytokine production in chorioamnionitis, J. Reprod. Immunol., 2000, vol. 47, pp. 185–196.
Hormones of the gonads: Estradiol, progesterone, and testosterone, their structure, mechanism of action, and biological role. https://infopedia.su/16x7226.html.
Brigadirov, Yu.N., Kotsarev, V.N., Shaposhnikov, I.T., Lobanov, A.E., Volkova, I.V., and Kopytina, K.O., Signal proteins and steroid hormones as markers of inflammatory processes in the reproductive organs of sows, Vopr. Normativno-Pravovogo Regul. Vet., 2018, no. 3, pp. 71–74.
Important hormones during pregnancy. https://flovit.ru/beremennost/diagnostika/gormon-beremennosti.html.
Sidel’nikova, V.M., Nevynashivanie beremennosti (Miscarriage), Moscow: Meditsina, 1986.
Macias, H. and Hinck, L., Mammary gland development, Wiley Interdiscip. Rev., Dev. Biol., 2012, vol. 1, no. 4, pp. 533–557.
Progesterone and inflammatory responses in the cervix. https//biliofond.ru/view.aspx?id=729816.
Estrogens. Role in the body. Pros and cons of the uterus. https://infopedia.su/8xd2d8.html.
Estradiol during pregnancy. http://spuzom.com/estradiol-pri-beremennosti.html.
Balashov, N.G., Biometric methods of processing materials in biological research (calculating the confidence factor), in Veterinarnyi kontrol' pri iskusstvennom osemenenii zhivotnykh (Veterinary Control in Artificial Insemination of Animals), Moscow: Kolos, 1980, pp. 231–235.
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Kotsarev, V.N., Nezhdanov, A.G. & Boev, V.Y. Parameters for Concentrations of Sows’ Gonadal Steroids in Predicting Inflammatory Processes in the Reproductive Tract. Russ. Agricult. Sci. 46, 184–186 (2020). https://doi.org/10.3103/S106836742002010X
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DOI: https://doi.org/10.3103/S106836742002010X