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GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients

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Abstract

Carriers of GSTT1 gene deletion were found to be more subject to a risk of emerging non-small-cell lung cancer (NSLC) than those of normal GSTT1(+) genotype. A study of the relation between GST gene polymorphism and cytogenetic indices in lung cancer patients has shown a significant excess of the group average level in cells with micronuclei in NSLC patients with GSTT1(−). The frequency of cells with micronuclei was higher in smoking patients with a mutant genotype than in smoking carriers of the GSTT1(+) genotype.

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Authors and Affiliations

  1. Institute of Genetics and Cytology, National Academy of Sciences of Belarus, Minsk, Belarus

    N. N. Chakova, E. P. Mikhalenko, S. N. Polonetskaya, N. V. Chebotareva, O. V. Kvitko & E. V. Krupnova

  2. Clinical Oncological Dispensary, Minsk, Belarus

    Y. E. Demidchik & A. A. Zhilko

Authors
  1. N. N. Chakova
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  2. E. P. Mikhalenko
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  3. S. N. Polonetskaya
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  4. N. V. Chebotareva
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  5. Y. E. Demidchik
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  6. A. A. Zhilko
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  7. O. V. Kvitko
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  8. E. V. Krupnova
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Corresponding author

Correspondence to N. N. Chakova.

Additional information

Original Russian Text © N.N. Chakova, E.P. Mikhalenko, S.N. Polonetskaya, N.V. Chebotareva, Y.E. Demidchik, A.A. Zhilko, O.V. Kvitko, E.V. Krupnova, 2009, published in Tsitologiya i Genetika, 2009, Vol. 43, No. 1, pp. 50–55.

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Chakova, N.N., Mikhalenko, E.P., Polonetskaya, S.N. et al. GST polymorphism and cytogenetic changes in lung tissues of lung cancer patients. Cytol. Genet. 43, 38–41 (2009). https://doi.org/10.3103/S0095452709010071

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  • DOI: https://doi.org/10.3103/S0095452709010071

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