Literatur review: Peran selenium pada diare akut anak

Nolitriani Nolitriani* -  Fakultas Kedokteran Universitas Andalas - RSUP Dr. M. Djamil Padang, Indonesia
Yusri Dianne Jurnalis -  Subbagian Gastrohepatologi Anak Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil Padang, Jl. Perintis Kemerdekaan, Padang, Indonesia
Yorva Sayoeti -  Subbagian Gastrohepatologi Anak Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil Padang, Jl. Perintis Kemerdekaan, Padang
Acute diarrhea is a manifestation of gastrointestinal dysfunction. If it lasts more than 14 days is called persistent diarrhea. Diarrhea is a leading cause of death in infants and children in Indonesia. Acute diarrhea is a gastrointestinal disease that is considered oxidative stress. Selenium is also thought to be involved in the acute diarrhea process because it contains the gastrointestinal glutathione peroxidase (GPx2 / GPx GI) enzyme which is most commonly found in the epithelial mucosa of the gastrointestinal tract. The aim of this review is to study and analyze the role of selenium in the treatment of pediatric acute diarrhea. This study is a literature review with a narrative method that analyzes research related to the role of selenium in the treatment of acute diarrhea. The results of this study indicate that the administration of selenium reduces the duration of diarrhea. The conclusion of this study is selenium functions in the process of healing acute diarrhea

Keywords : Acute Diarrhea; Antioxidant; Micronutrient; Selenium

  1. Santosa B. Tatalaksana diare cair akut dalam naskah lengkap Kongres Nasional III Badan Koordinasi Gastroenterologi Anak Indonesia. In: Penanganan Optimal Masalah Saluran Cerna Dan Hati Pada Anak. Surabaya: Badan Koordinasi Gastroenterologi Anak Indonesia; 2007:35-45.
  2. Subagyo B, Santoso N. Diare Akut. In: Juffrie M, Soenarto S, Oswari H, Arief S, Rosalina I, eds. Buku Ajar Gastroenterologi- Hepatologi. 1st ed. Jakarta: IDAI; 2010:87-120.
  3. Kemenkes RI. Hasil Utama Riskesdas. Jakarta; 2018.
  4. Brown. Diarrhea and malnutrition. The Journal Of Nutrition. 2003;133(1):328-332. doi:https://doi.org/10.1093/jn/133.1.328S.
  5. Aggarwal R, Sentz J, Miller MA. Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses: A meta-analysis. Pediatrics. 2007;119(6):1120-1130. doi:10.1542/peds.2006-3481.
  6. Ölmez A, Yalçin S, Yurdakök K, Coşkun T. Serum selenium levels in acute gastroenteritis of possible viral origin. Journal of Tropical Pediatrics. 2004;50(2):78-81. doi:10.1093/tropej/50.2.78.
  7. Kleinman RE, Goulet OJ, Vergani GM, Sanderson PM, Sherman PM SB. Acute diarrhea. In: Mehta L, ed. Walker’s Pediatric Gastrointestinal Disease. 6th ed. United States of America: People’s medical publid=shing house; 2018:1028.
  8. Ramig R. Pathogenesis of Intestinal and Systemic Rotavirus Infection. Journal of Virology. 2004;78(19):10213-10220. doi:10.1128/jvi.78.19.10213-10220.2004.
  9. Dwipoerwantoro PG, Lukito W, Aulia D, Arnaud J, Roussel AM. Selenium status and fungi in the protein-losing enteropathy of persistent diarrhea. Asia Pacific Journal of Clinical Nutrition. 2017;26(March):S79-S84. doi:10.6133/apjcn.062017.s13.
  10. Ferencik M, Ebringer L. Modulatory effect of selenium and zinc on the immune system. Folia Microbiol (Praha). 2003;48(3):417-426. doi:10.1007/BF02931378.
  11. Ekweagwu E, Agwu A, Madukwe E. The role of micronutrients in child health: A review of the literature. African Journal of Biotechnology. 2016;7(21):3804-3810. doi:10.5897/AJB08.388.
  12. Tinggi U. Selenium: Its role as antioxidant in human health. Environmental Health and Preventive Medicine. 2008;13(2):102-108. doi:10.1007/s12199-007-0019-4.
  13. Satoto. Selenium dan kurang yodium. Jurnal GAKY Indonesia (Indonesian journal of IDD). 2002;1(1):33-42.
  14. Fan AM, Kizer KW. Selenium. Nutritional, toxicologic, and clinical aspects. Western Journal of Medicine. 1990;153(2):160-167. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1002502/.
  15. MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C, Burk RF, Dunn JR, Green AL, Hammond R, Schaffner W, Jones TF. Acute selenium toxicity associated with a dietary supplement. Archives of Internal Medicine. 2010;170(3):256-261. doi:10.1001/archinternmed.2009.495.
  16. Litov RE, Combs GF. Selenium in pediatric nutrition. Pediatrics. 1991;87(3):339-351.
  17. Sinaga M, Supriatmo S, Evalina R, Yudiyanto AR, Sinuhaji AB. Selenium for acute watery diarrhea in children. Paediatrica Indonesiana. 2016;56(3):139. doi:10.14238/pi56.3.2016.139-43.
  18. Arthur JR, McKenziey RC, Beckett GJ. Selenium in the Immune System. Sciences-New York. 2003;133(5 Suppl 1):1452S-6S.
  19. Zoidis E, Seremelis I, Kontopoulos N, Danezis GP. Selenium-dependent antioxidant enzymes: Actions and properties of selenoproteins. Antioxidants. 2018;7(5):1-26. doi:10.3390/antiox7050066.
  20. Jurkovič S, Osredcar J, Marc J. Molecular impact of glutathione peroxidases in antioxidant processes. Biochemia Medica. 2008;18(2):162-174.
  21. Thomson CD. Assessment of requirements for selenium and adequacy of selenium status: A review. European Journal of Clinical Nutrition. 2004;58(3):391-402. doi:10.1038/sj.ejcn.1601800.
  22. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Supplementation with selenium and human immune cell functions - II. Effect on cytotoxic lymphocytes and natural killer cells. Biological Trace Element Research. 1994;41(1-2):115-127. doi:10.1007/BF02917222.
  23. Beck M a, Levander O a, Handy J. Oxidative Stress Mediated by Trace Elements Selenium Deficiency and Viral Infection 1. Journal of Nutrition. 2003;133(7):1463-1467.
  24. Beck MA. Nutritionally induced oxidative stress: Effect on viral disease. American Journal of Clinical Nutrition. 2000;71(6 SUPPL.):1676-1679. doi:10.1093/ajcn/71.6.1676s.
  25. Esmaeili S, Fazelifard RS, Ahmadzadeh S, Shokouhi M. The importance of Selenium on human health. KAUMS Journal (FEYZ). 2013;16(7):779-780.
  26. Beck MA, Nelson HK, Shi Q, Dael P Van, Schiffrin EJ, Blum S, Barclay D, Levander OA. Selenium deficiency increases the pathology of an influenza. The FASEB Journal. 2001;15(4):1481-1483. doi:https://doi.org/10.1096/fj.00-0721fj.
  27. Bass DM. Rotavirus, Caliciviruses and Astroviruses. In: Kliegman RM, Geme JWS, Blum NJ, Shah SS, Tasker RC, Wilson KM, Behrman RE, eds. Nelson Texbook of Pediatrics. 21st ed. Philadelphia: Elsevier; 2020:7022.
  28. Wingler K, Müller C, Schmehl K, Florian S, Brigelius-Flohé R. Gastrointestinal Glutathione Peroxidase Prevents Transport of Lipid Hydroperoxides in CaCo-2 Cells ¨. Gastroenterology. 2000;119(2):420-430. doi:10.1053/gast.2000.9521.
  29. Boyne R, Arthur JR. The response of selenium-deficient mice to Candida albicans infection. Journal of Nutrition. 1986;116(5):816-822. doi:10.1093/jn/116.5.816.
  30. Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G. Regulation of cellular immune responses by selenium. Biological Trace Element Research. 1992;33(1-3):23-35. doi:10.1007/BF02783989.
  31. Kiremidjian-Schumacher L, Roy M, Wishe H, Cohen M, Stotzky G. Selenium and Immune Cell Functions. Zeitschrift fur Ernahrungswissenschaft. 1998;37(Suppl. 1):50-56. https://europepmc.org/article/med/9558729.

Open Access Copyright (c) 2020 Nolitriani Nolitriani, Yusri Dianne Jurnalis, Yorva Sayoeti
Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

AcTion: Aceh Nutrition Journal
Published by: Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health.
Soekarno-Hatta Street, No. 168. Health Polytechnic of Aceh, Aceh Besar, 23352. Telp/Fax: 0651 46126 / 0651 46121.
Website: https://gizipoltekkesaceh.ac.id/
E-mail: [email protected]

e-issn: 2548-5741, p-issn: 2527-3310

All content is licensed under a: Creative Commons Attribution ShareAlike 4.0 International License

View My Stats

Get a feed by atom here, RRS2 here and OAI Links here