Authors
1 Community Health Department, College of Health and Medical Technology, Kufa, Iraq
2 Department of Applied Sciences, University of Technology, Baghdad, Iraq
Abstract
The study aims to investigate the effects of silver nanoparticles (Ag NPs) on the seminiferous tubules in Albino rats. Several in vitro studies have been performed in different cell models, using various nanoparticles. Pure and spherical AgNPs with an average size of 30 nm, was injected into two groups of male albino rats (6 rats for each group) in different doses. Histopathological changes in testis tissues were showed a harmful effect of the silver nanoparticles, manifested by reducing the number of spermatogenic cells, and a decrease in the number of leyidg´s cells (group 1), and hypotrophy in seminiferous and enlargement in interstitial spaces in group 2.
Keywords
[2] A. K. Ali, “One-step synthesis of copper oxide nanoparticles using pulsed laser ablation in water: influence of the laser wavelengths on optical properties,” Eng. & Tech. Journal, 31, 7, 894, 2013.
[3] E. A. S. AL-Rubaee, A. K. Ali, A. A. Salman and Z. A. Salman, “Inhibition effect of noble metals nanoparticles on acid Phosphate activity in sera of healthy subject,” Eng. &Tech. Journal, B, 33, 1, 1-11, 2015.
[4] J.H. Ji, J.H. Jung, S. S. Kim, J. U. Yoon, J. D. Park, B. S. Choi, Y. H. Chung, I. H. Kwon, J. Jeong, B. S. Han, J. H. Shin, J. H. Sung, K. S. Song and I. J. Yu, “Twenty-eight-day inhalation toxicity study of silver nanoparticles in Sprague-Dawley rats,” Inhalation Toxicol. 19, 857-871, 2007.
[5] H. W. Chen, S. F. Su, C. T. Chien, W. H. Lin, S. L. Yu, C. C. Chou, J. J. Chen and P. C.Yang, “Titanium dioxide nanoparticles induce emphysema-like lung injury in mice,” Federation American Soci. Experiment. Biol. J., 20, 13, 2393-5, 2006.
[6] S. M. Hussain, K. I. Hess, J. M. Gearhart, K. T. Geiss and J. J. Schlager, “In vitro toxicity of nanoparticles in BRL 3A rat liver cells,” Toxicol. In Vitro, 19, 975-986, 2005.
[7] N. R. Yacobi, H. C. Phuleria, L. Demaio, C. H. Liang, C. A. Peng, C. Sioutas, Z. Borok, K. J. Kim and E. D. Crandall, “Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties,” Toxicol. In Vitro, 21, 1373–1381, 2007.
[8] H. J. Johnston, G. Hutchison, F. M. Christensen, S. Peters, S. Hankin and V. A. Stone, “A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity,” Crit. Rev. Toxicol., 40, 328-46, 2010.
[9] L. Braydich-Stolle, S. Hussain, J. J. Schlager, M. C. Hofmann, “In vitro cytotoxicity of nanoparticles in mammalian germline stem cells,” Toxicol. Sci., 88, 412-9, 2010.
[11] P Witthawaskul, D. Kanjanapothi, T. Taesothikul and N. Lertprasertsuke, “Acute and subacute toxicities of saponin mixture isolated from Schefflera leucantha Viguier,” J. Ethnopharmacol., 89, 115-121, 2003.
[12] K. K. Turekian, “Oceans,” Prentice-Hall foundations of earth science series, 2nd Edition, 1968.
[13] L.L. Vacca, “Laboratory Manual of Histochemistry,” 1st ed., Raven Press: New York, USA, 1985.
[14]X .P. Zhu. T. Suzuki. T. Nakayama, H. Suematsu. W. Jiang, K. Niihara, “Underwater laser ablation approach to fabricating monodisperse metallic nanoparticles,” Chemical Physics Letters, 427, 127-131, 2006.
[15] N.V. Tarasenko, A.V. Butsen, E.A. Nevar, N.A. Savastenko , “Synthesis of nanosized particles during laser ablation of gold in water,” Applied Surface Science, 252, 4439-4444, 2006.
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