In Japan, patients affected by malignancies, including hepatocellular carcinoma (HCC), are growing older. Although therapeutic approaches for HCC have been continuously improving, there is little evidence to support an optimal treatment strategy for elderly patients with HCC. Here, we describe three elderly patients aged ≥90 years with HCC successfully treated by non-surgical therapies, such as radiofrequency ablation and transarterial chemoembolization. Although they were complicated by several underlying diseases, all patients exhibited favorable performance status, liver function, and cognition function. In conclusion, the administration of therapy for HCC should be considered even in patients aged ≥90 years in view of the characteristics of the tumor and patient's condition. In such cases, both the prevention of comorbidity deterioration and management of postoperative complications are highly important.
