1887
  1. Home
  2. Eurosurveillance
  3. Volume 25, Issue 15, 16/Apr/2020
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

Since 2015 in the United States (US), the US urethritis clade (US_NmUC) has caused a large multistate outbreak of urethritis among heterosexual males. Its ‘parent’ strain caused numerous outbreaks of invasive meningococcal disease among men who have sex with men in Europe and North America. We highlight the arrival and dissemination of US_NmUC in the United Kingdom and the emergence of multiple antibiotic resistance. Surveillance systems should be developed that include anogenital meningococci.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2020.25.15.2000375
2020-04-16
2024-05-17
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.15.2000375
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/25/15/eurosurv-25-15-1.html?itemId=/content/10.2807/1560-7917.ES.2020.25.15.2000375&mimeType=html&fmt=ahah

References

  1. Retchless AC, Kretz CB, Chang HY, Bazan JA, Abrams AJ, Norris Turner A, et al. Expansion of a urethritis-associated Neisseria meningitidis clade in the United States with concurrent acquisition of N. gonorrhoeae alleles. BMC Genomics. 2018;19(1):176.  https://doi.org/10.1186/s12864-018-4560-x  PMID: 29499642 
  2. Fifer H, Saunders J, Soni S, Sadiq ST, FitzGerald M. 2018 UK national guideline for the management of infection with Neisseria gonorrhoeae. Int J STD AIDS. 2020;31(1):4-15.  https://doi.org/10.1177/0956462419886775  PMID: 31870237 
  3. Ma KC, Unemo M, Jeverica S, Kirkcaldy RD, Takahashi H, Ohnishi M, et al. Genomic Characterization of Urethritis-Associated Neisseria meningitidis Shows that a Wide Range of N. meningitidis Strains Can Cause Urethritis. J Clin Microbiol. 2017;55(12):3374-83.  https://doi.org/10.1128/JCM.01018-17  PMID: 28904187 
  4. Bazan JA, Turner AN, Kirkcaldy RD, Retchless AC, Kretz CB, Briere E, et al. Large Cluster of Neisseria meningitidis Urethritis in Columbus, Ohio, 2015. Clin Infect Dis. 2017;65(1):92-9.  https://doi.org/10.1093/cid/cix215  PMID: 28481980 
  5. Bazan JA, Tzeng YL, Stephens DS, Carter AM, Brown MA, Snyder B, et al. Repeat Episodes of Symptomatic Urethritis Due to a Uropathogenic Meningococcal Clade. Sex Transm Dis. 2020;47(1):e1-4.  https://doi.org/10.1097/OLQ.0000000000001079  PMID: 31651709 
  6. Kretz CB, Bergeron G, Aldrich M, Bloch D, Del Rosso PE, Halse TA, et al. Neonatal Conjunctivitis Caused by Neisseria meningitidis US Urethritis Clade, New York, USA, August 2017. Emerg Infect Dis. 2019;25(5):972-5.  https://doi.org/10.3201/eid2505.181631  PMID: 31002061 
  7. Tzeng YL, Bazan JA, Turner AN, Wang X, Retchless AC, Read TD, et al. Emergence of a new Neisseria meningitidis clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen. Proc Natl Acad Sci USA. 2017;114(16):4237-42.  https://doi.org/10.1073/pnas.1620971114  PMID: 28373547 
  8. Kupferschmidt K. Infectious diseases. Bacterial meningitis finds new niche in gay communities. Science. 2013;341(6144):328.  https://doi.org/10.1126/science.341.6144.328  PMID: 23888010 
  9. Folaranmi TA, Kretz CB, Kamiya H, MacNeil JR, Whaley MJ, Blain A, et al. Increased Risk for Meningococcal Disease Among Men Who Have Sex With Men in the United States, 2012-2015. Clin Infect Dis. 2017;65(5):756-63.  https://doi.org/10.1093/cid/cix438  PMID: 28505234 
  10. Miglietta A, Fazio C, Neri A, Pezzotti P, Innocenti F, Azzari C, et al. Interconnected clusters of invasive meningococcal disease due to Neisseria meningitidis serogroup C ST-11 (cc11), involving bisexuals and men who have sex with men, with discos and gay-venues hotspots of transmission, Tuscany, Italy, 2015 to 2016. Euro Surveill. 2018;23(34).  https://doi.org/10.2807/1560-7917.ES.2018.23.34.1700636  PMID: 30153883 
  11. Lucidarme J, Hill DM, Bratcher HB, Gray SJ, du Plessis M, Tsang RS, et al. Genomic resolution of an aggressive, widespread, diverse and expanding meningococcal serogroup B, C and W lineage. J Infect. 2015;71(5):544-52.  https://doi.org/10.1016/j.jinf.2015.07.007  PMID: 26226598 
  12. Taha MK, Claus H, Lappann M, Veyrier FJ, Otto A, Becher D, et al. Evolutionary Events Associated with an Outbreak of Meningococcal Disease in Men Who Have Sex with Men. PLoS One. 2016;11(5):e0154047.  https://doi.org/10.1371/journal.pone.0154047  PMID: 27167067 
  13. Lucidarme J, Lekshmi A, Parikh SR, Bray JE, Hill DM, Bratcher HB, et al. Frequent capsule switching in ‘ultra-virulent’ meningococci - Are we ready for a serogroup B ST-11 complex outbreak? J Infect. 2017;75(2):95-103.  https://doi.org/10.1016/j.jinf.2017.05.015  PMID: 28579305 
  14. Grumach AS, Kirschfink M. Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach. Mol Immunol. 2014;61(2):110-7.  https://doi.org/10.1016/j.molimm.2014.06.030  PMID: 25037634 
  15. Nolfi-Donegan D, Konar M, Vianzon V, MacNeil J, Cooper J, Lurie P, et al. Fatal Nongroupable Neisseria meningitidis Disease in Vaccinated Patient Receiving Eculizumab. Emerg Infect Dis. 2018;24(8):1561-4.  https://doi.org/10.3201/eid2408.180228  PMID: 30015608 
  16. Ladhani SN, Campbell H, Lucidarme J, Gray S, Parikh S, Willerton L, et al. Invasive meningococcal disease in patients with complement deficiencies: a case series (2008-2017). BMC Infect Dis. 2019;19(1):522.  https://doi.org/10.1186/s12879-019-4146-5  PMID: 31200658 
  17. Bratcher HB, Corton C, Jolley KA, Parkhill J, Maiden MC. A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes. BMC Genomics. 2014;15(1):1138.  https://doi.org/10.1186/1471-2164-15-1138  PMID: 25523208 
  18. Huson DH. SplitsTree: analyzing and visualizing evolutionary data. Bioinformatics. 1998;14(1):68-73.  https://doi.org/10.1093/bioinformatics/14.1.68  PMID: 9520503 
Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 – emergence of multiple antibiotic resistance calls for vigilance
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Avril+Brooks&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brooks Avril</a>, <a href="/search?value1=Jay+Lucidarme&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lucidarme Jay</a>, <a href="/search?value1=Helen+Campbell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Campbell Helen</a>, <a href="/search?value1=Laura+Campbell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Campbell Laura</a>, <a href="/search?value1=Helen+Fifer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fifer Helen</a>, <a href="/search?value1=Steve+Gray&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gray Steve</a>, <a href="/search?value1=Gwenda+Hughes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hughes Gwenda</a>, <a href="/search?value1=Aiswarya+Lekshmi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lekshmi Aiswarya</a>, <a href="/search?value1=Gabriel+Schembri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schembri Gabriel</a>, <a href="/search?value1=Michael+Rayment&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rayment Michael</a>, <a href="/search?value1=Shamez+N+Ladhani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ladhani Shamez N</a>, <a href="/search?value1=Mary+E+Ramsay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramsay Mary E</a>, <a href="/search?value1=Ray+Borrow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Borrow Ray</a></span>. Detection of the United States Neisseria meningitidis urethritis clade in the United Kingdom, August and December 2019 – emergence of multiple antibiotic resistance calls for vigilance. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(15):pii=2000375. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.15.2000375" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.15.2000375</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 20 Mar 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 15 Apr 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.15.2000375
/content/10.2807/1560-7917.ES.2020.25.15.2000375
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error