Ti Catalyzed Hydroamination: A Direct Functionalization of Cu Acetylide

27 December 2019, Version 1
This content is a preprint and has not undergone peer review at the time of posting.

Abstract

In the presence of a bis-amidate-bis-amido Ti pre-catalyst, an NHC supported Cu acetylide was reacted with p-toluidine to generate a new Cu containing species almost quantitatively. The product was analyzed by NMR spectroscopy and X-ray single crystal diffraction to be a Cu enamide. Preliminary mechanistic studies suggest the reaction follows well accepted [2+2] cycloaddition mechanism for early transition metal catalyzed hydroamination. Furthermore, the reaction is likely to be a direct functionalization of the alkyne moiety of the Cu acetylide.

Keywords

metal acetylide
Hydroamination reactions
Early transition metal
Catalysis

Supplementary materials

Title
Description
Actions
Title
ls764 a
Description
Actions
Title
Supporting information of Ti Catalyzed Hydroamination A Direct Functionalization of Cu Acetylide
Description
Actions

Comments

Comments are not moderated before they are posted, but they can be removed by the site moderators if they are found to be in contravention of our Commenting Policy [opens in a new tab] - please read this policy before you post. Comments should be used for scholarly discussion of the content in question. You can find more information about how to use the commenting feature here [opens in a new tab] .
This site is protected by reCAPTCHA and the Google Privacy Policy [opens in a new tab] and Terms of Service [opens in a new tab] apply.