New and evolving therapies for hereditary angioedema
Hereditary angioedema (HAE) is a rare, autosomal dominant, genetic disorder associated with a deficiency in C1 inhibitor protein. HAE is characterized by recurrent and unpredictable episodes of swelling of the extremities, abdomen, face, and upper airway. There are several newly approved
drugs as well as investigational products that are currently under study for the management of patients with HAE, with the potential to optimize care and improve quality of life for patients with HAE. We reviewed the evolution of HAE treatment options in the United States and discussed mechanisms
of action, routes of administration, and efficacy of these therapies.
Keywords: Angioedema; C1 esterase inhibitor; allergy; bradykinin; complement; hereditary; immunology; kallikrein; swelling; treatment
Document Type: Research Article
Publication date: 01 January 2019
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