Roughened surface was formed on the surface of cobalt-chromium-molybdenum (Co-Cr-Mo) alloy substrate by sandblasting method using silicon carbide grinding particles with 3 μm in average diameter. In order to impart apatite formation ability to the Co-Cr-Mo alloy, the substrate was immersed in simulated body fluid (SBF) adjusted at higher pH in comparison with that of conventional SBF and subsequently the SBF was heated. When thus-treated substrate was immersed in physiological SBF, apatite formation was induced by the calcium phosphate film and the apatite covered the whole surface of the substrate within 1 day. The formed apatite layer adhered to the Co-Cr-Mo alloy substrate by mechanical anchoring effect.