Inclusion complexes of amlodipine besylate and cyclodextrins

Agneš Kapor; Vesna Nikolić; Ljubiša Nikolić; Mihajlo Stanković; Milorad Cakić; Ljiljana Stanojević; Dušica Ilić

doi:10.2478/s11532-010-0061-8

Open Access Published by De Gruyter Open Access June 17, 2010

Inclusion complexes of amlodipine besylate and cyclodextrins

Agneš Kapor , Vesna Nikolić , Ljubiša Nikolić , Mihajlo Stanković , Milorad Cakić , Ljiljana Stanojević and Dušica Ilić

From the journal Open Chemistry

https://doi.org/10.2478/s11532-010-0061-8

Abstract

In this paper the procedure for the preparation of inclusion complexes of amlodipine besylate with β-cyclodextrin (β-CD) and 2-hydrohypropyl-β-cyclodextrin (HPβ-CD) and their structural characterization was described. Molecular inclusion complexes of amlodipine besylate are prepared by the coprecipitation method and characterised by the application of spectroscopic methods FTIR, 1H-NMR and XRD. The photosensitivity of amlodipine besylate in the inclusion complexes was also determined with respect to uncomplexed agent. DSC curves indicate the loss of the clear peak due to melting of amlodipine besylate at about 200°C, while on XR diffractograms certain reflections are lost belonging to amlodipine besylate in complexes. This indicates its inclusion in the vacancies of the host. The inclusion of amlodipine besylate with cyclodextrins increases the stability, i.e. decreases the photosensitivity of amlodipine besylate.

Keywords: Amlodipine besylate; Inclusion complexes; Cyclodextrins; Spectroscopic methods; Photosensitivity

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Published Online: 2010-6-17

Published in Print: 2010-8-1

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Inclusion complexes of amlodipine besylate and cyclodextrins

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