Abstract
Number of novel derivatives of dihydrotriazolo-and-tetrazolopyrimidines containing carboxamide group in position 6 were obtained by multicomponent Biginelli-type reaction. The structures of all synthesized compounds were proved by NMR and MS spectral methods. The method of three-component Biginelli-type reaction is well suited for the synthesis of new promising dihydroazolopyrimidines providing a scaffold for screening of biological activity.
[1] Atwal, K. S. and Moreland, S., Bioorg. Med. Chem. Lett. 1, 291 (1991). http://dx.doi.org/10.1016/S0960-894X(01)80810-610.1016/S0960-894X(01)80810-6Search in Google Scholar
[2] Nobunao, T., Tadashi, M., Minoru, O., Kazuhiko, A., Atsushi, I., and Tadao, M., Jpn. Kokai Tokkyo Koho 11, 180 (1988). Search in Google Scholar
[3] Fedorova, O. V., Zhidovinova, M. S., Rusinov, G. L., and Ovchinnikova, I. G., Russ. Chem. Bull. (Engl. Transl.) 8, 1768 (2003). http://dx.doi.org/10.1023/A:102605260395110.1023/A:1026052603951Search in Google Scholar
[4] Desenko, S. M., Gladkov, E. S., Sirko, S. N., and Khanetskii, B. B., Vestn. Kharkiv. Univ., Ser. Khim. 596, 10, 56 (2003). Search in Google Scholar
[5] Pryadeina, M. V., Burgart, Y. V., Saloutin, V. I., Kodess, M. I., Ulomskii, E. N., and Rusinov, V. L., Russ. J. Org. Chem. (Engl. Transl.) 40, 902 (2004). Search in Google Scholar
[6] Reiter, J. and Rivo, E., J. Heterocycl. Chem. 26, 971 (1989). http://dx.doi.org/10.1002/jhet.557026041610.1002/jhet.5570260416Search in Google Scholar
[7] Miriyala, B. and Williamson, J. S., Tetrahedron Lett. 44, 7957 (2003). http://dx.doi.org/10.1016/j.tetlet.2003.08.11810.1016/j.tetlet.2003.08.118Search in Google Scholar
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