ORIGINAL ARTICLE   Free access

Italian Journal of Dermatology and Venereology 2023 December;158(6):429-36

DOI: 10.23736/S2784-8671.23.07533-3

Copyright © 2023 EDIZIONI MINERVA MEDICA

language: English

An easy to use, ceramide-containing skincare routine: effectiveness and improvement of quality of life in elderly patients with xerosis

Federica FILIPPI ^{1, 2} ✉, Marco A. CHESSA ^{1, 2}, Federico BARDAZZI ^{1, 2}, Alessandro PILERI ^{1, 2}, Annalisa PATRIZI ^{1, 2}

¹ Dermatology Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; ² Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy

BACKGROUND: Xerosis negatively impacts the quality of life (QoL) for older adults by producing pruritus (itching), burning or stinging, and an uncomfortable sensation of tightness in the skin. Furthermore, chronic illness and pharmacological therapies could worsen skin health. Severe xerosis can also result in redness or cracking of the skin. The aim of this prospective open-label trial is to evaluate the effectiveness of a ceramide-based moisturizing cream and cleanser routine on elderly xerosis.
METHODS: During the 4-week treatment study, patients followed the routine according to the established protocol. At different timepoints (baseline, visit 1; after 28±5 days, visit 2) evaluations on the skin health and QoL of the patients were conducted by a healthcare professional (HCP), along with a patients’ self-evaluation.
RESULTS: The study demonstrates that the treatment with the investigated products determines an overall significant improvement in all skin dryness criteria. In particular, after the observational period: 93% of the subjects had no or minimal skin roughness; 96% of patients had no or minimal discomfort due to skin dryness; 97% of patients did not present any fissures; patient self-assessments on skin dryness were consistent with HCP evaluation. QoL has globally improved in all patients, with a significant reduction of embarrassment, and a positive impact on social and daily activities. Patients’ overall satisfaction was high in 87% of patients and 93% of them stated that they would continue the treatment also after the study had been completed.
CONCLUSIONS: After 4 weeks, the daily use of a ceramide-based routine significantly improved signs and symptoms of senile xerosis and chronic discomfort associated with xerosis in elderly adults. Furthermore, the impact of senile xerosis on subjects’ QoL was also reduced after 4 weeks. The subjects also reported high satisfaction with the skincare regimen and its results.

KEY WORDS: Ichthyosis; Priritus; Ceramides; Skin cream; Aged