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ORIGINAL ARTICLE
The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2021 March;65(1):59-63
DOI: 10.23736/S1824-4785.19.03130-3
Copyright © 2019 EDIZIONI MINERVA MEDICA
language: English
Baseline PET as prognostic index in diffuse large B-cell lymphoma and grade IIIb follicular lymphoma: a retrospective study of a single-center experience
Leonardo CAMPIOTTI 1 ✉, Diego DE PALMA 2, Luigina GUASTI 1, Ilaria PROSERPIO 3, Sabrina CASAGRANDE 2, Ilaria SCHIORLIN 2, Elena BOLZACCHINI 3, Matteo SUTER 3, Francesca OGLIARI 3, Alessandro SQUIZZATO 1
1 Department of Medicine and Surgery, University of Insubria, Varese, Italy; 2 Department of Nuclear Medicine, Ospedale di Circolo e Fondazione Macchi, ASST Settelaghi, Varese, Italy; 3 Department of Medical Oncology, Ospedale di Circolo e Fondazione Macchi, ASST Settelaghi, Varese, Italy
BACKGROUND: International guidelines support performing baseline positron emission tomography (PET) in lymphoma. Metabolic tumor volume (MTV) measurement has been proposed as a good measurement of disease burden. We investigated if MTV at baseline PET can be predictive of complete response (CR) to first line standard chemotherapy in diffuse large B-cell lymphoma (DLBCL) and in follicular lymphoma (FL) grade IIIb.
METHODS: We retrospectively analyzed data on 54 consecutive patients with DLBCL and FL grade IIIb treated in our institution. Dedicated software automatically estimated the SUV
RESULTS: At the univariate logistic regression analysis, patients with a MTV28 lower than the median value (173.1) had an odds ratio (OR) of 4 (95% CI: 0.94-16.9) of obtaining a CR in comparison to patients with a MTV 28 higher than the median value; patients with a MTV42 lower than the median value (i.e. 85.6) had an OR of 3.63 (95% CI: 0.85-15.34) of obtaining a CR in comparison to patients with a MTV 42 equal or higher than the median value. Using MTV28/MTV42 value with median as cut-off instead of MTV28, patients with a MTV28/MTV42 lower than the median value (i.e. 1.81) had an OR of 4.26 (95% CI: 0.72-25.07) and of 7.54 (95% CI: 0.70-80.91) of obtaining a CR in comparison to patients with a MTV28/MTV42 equal or higher than the median value in the two models, respectively.
CONCLUSIONS: The results of our study suggest that MTV could be a useful tool to predict response to R-CHOP in patients affected with DLBCL and FL grade IIIb and that a multi-parameters evaluation should be considered.
KEY WORDS: Plasmablastic lymphoma; Follicular lymphoma; Positron-emission tomography; Tumor burden