CASE REPORT   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 May;178(5):348-52

DOI: 10.23736/S0393-3660.18.03795-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

A rare spinal localization of gray zone lymphoma without mediastinal involvement: a case report and review of literature

Vanessa INNAO ¹ ✉, Alessandro ALLEGRA ¹, Francesco BACCI ², Andrea G. ALLEGRA ¹, Doriana VADDINELLI ¹, Caterina MUSOLINO ¹

¹ Division of Hematology, Department of Human Pathology of Adult and Evolutionary Age “Gaetano Barresi,” University of Messina, Messina, Italy; ² Section of Hematopathology, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy

The “Gray-Zone Lymphomas” represent histological entities that are interposed between Hodgkin’s lymphoma and Non-Hodgkin’s Lymphoma. We report the case of a man diagnosed with a Lymphoma B unclassifiable with intermediate characteristics between Hodgkin’s lymphoma and a large cell lymphoma B, with a rare spinal localization. We decided to treat him with Adriamycin, Bleomycin, Vinblastine, Dacarbazine and anti-CD20 antibody, achieving a complete response. We here discuss histopathologic patterns, and work-up of this pathological entity, and we demonstrated that more intensive therapy do not always correlate with better therapeutic goals, inviting to analyze each case.

KEY WORDS: Hodgkin Disease - Lymphoma, Non-Hodgkin - Drug therapy - Spine