ORIGINAL ARTICLE   

Chirurgia 2022 April;35(2):76-81

DOI: 10.23736/S0394-9508.21.05267-0

Copyright © 2021 EDIZIONI MINERVA MEDICA

language: English

The place of thiol/disulfide homeostasis parameters in acute gallstone cholecystitis diagnosis

Necattin FIRAT ¹, Kayhan OZDEMIR ², Baris MANTOGLU ² ✉, Ali MUHTAROGLU ², Bahri ELMAS ³, Hayrullah YAZAR ⁴, Fatih ALTINTOPRAK ¹

¹ Department of General Surgery, Faculty of Medicine, Sakarya University Medical Faculty, Sakarya, Turkey; ² Department of General Surgery, Sakarya University Teaching and Research Hospital, Sakarya, Turkey; ³ Department of Pediatrics, Faculty of Medicine, Sakarya University Medical Faculty, Sakarya, Turkey; ⁴ Department of Biochemistry, Faculty of Medicine, Sakarya University Medical Faculty, Sakarya, Turkey

BACKGROUND: Thiol/disulfide homeostasis protects the organism from oxidative damage and plays a role in many physiological events. We aimed to investigate whether thiol/disulfide homeostasis parameters have changed in acute cholecystitis patients and the spot of this parameter in the diagnosis of the disease.
METHODS: There were 48 healthy and 48 acute cholecystitis patients in the prospective study. It was similar in age and gender between the two groups. Biochemical tests and thiol/disulfide homeostasis parameters were compared between the groups.
RESULTS: Disulfide and oxidized thiol levels were higher, and reduced thiol levels were lower in the patient group compared to the control group besides, the difference was statistically significant (P<0.05). There was no statistically significant difference in native thiol and total thiol.
CONCLUSIONS: In acute cholecystitis, thiol/disulfide homeostasis parameters are focused on the disulfide side, and we assume it may be a test that can be practiced in the diagnosis of the disease

KEY WORDS: Sulfhydryl compounds; Cholecystitis, acute; Diagnosis