Home > Journals > Minerva Dental and Oral Science > Past Issues > Minerva Stomatologica 2018 February;67(1) > Minerva Stomatologica 2018 February;67(1):1-11

CURRENT ISSUE
 

JOURNAL TOOLS

Publishing options
eTOC
To subscribe
Submit an article
Recommend to your librarian
 

ARTICLE TOOLS

Publication history
Reprints
Permissions
Cite this article as
Share

 

ORIGINAL ARTICLE   

Minerva Stomatologica 2018 February;67(1):1-11

DOI: 10.23736/S0026-4970.17.04084-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

language: English

Adjunctive use of an ethyl lauroyl arginate-(LAE-)-containing mouthwash in the nonsurgical therapy of periodontitis: a randomized clinical trial

Andrea PILLONI 1, Mauro CARERE 1, Germano ORRÙ 2, Alessandra SCANO 2, Cinzia TREZZA 1, Mariana A. ROJAS 3, Blerina ZEZA 1

1 Section of Periodontics, Department of Dentistry and Maxillofacial Surgery, Sapienza University, Rome, Italy; 2 Department of Surgical Science, University of Cagliari, Cagliari, Italy; 3 Department of Periodontics, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina


PDF


BACKGROUND: This randomized clinical trial evaluated the clinical and microbiological effects of 0.147% ethyl lauroyl arginate (LAE)-containing mouthwash compared to 0.12% chlorhexidine (CHX) mouthwash in the treatment of periodontitis.
METHODS: Subjects were randomized to use 0.147% LAE and 0.12% CHX mouthwash after professional mechanical plaque removal (PMPR) twice daily 1 hour after brushing for 4 weeks. Periodontal pocket depth (PPD), bleeding on probing (FMBS) and dental plaque (FMPS) were measured at baseline, 4 weeks and 3 months. Microbiological samples were taken at baseline, at 4 weeks and 3 months after plaque recording and prior to PPD and BoP measurements.
RESULTS: Forty subjects were randomized to treatment. Both therapies resulted in reduced FMPS, FMBS and residual pockets at 4 weeks and 3 months. The differences were not statistically significant. There were no treatment-related adverse events. Total bacterial count and the specific pathogens were reduced at 4 weeks and 3 months by both mouthwashes with no statistical differences between them at neither period of time.
CONCLUSIONS: A mouthwash containing 0.147% LAE could be an alternative to the use of 0.12% CHX in the non-surgical therapy of periodontitis considering the similar clinical effects, more stable microbiological improvement and absence of adverse effects.


KEY WORDS: Periodontal index - Chlorhexidine - N(alpha)-lauroylarginine ethyl ester - Mouthwashes - Periodontal diseases

top of page