DOI: 10.2337/dc06-1084 © 2006 by the American Diabetes Association
Does Coffee Consumption Reduce the Risk of Type 2 Diabetes in Individuals With Impaired Glucose?From the Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California Address correspondence and reprint requests to Deborah L. Wingard, PhD, Department of Family and Preventive Medicine, University of California San Diego, 9500 Gilman Dr. 0607, La Jolla, CA 92093-0607. E-mail: dwingard{at}ucsd.edu OBJECTIVEThe purpose of this study was to investigate the association between coffee intake and incident diabetes based on an oral glucose tolerance test (OGTT) and examine coffee habits in those with impaired glucose separately from those with normal glucose at baseline.
RESEARCH DESIGN AND METHODSIn this prospective study, 910 adults aged RESULTSPast and current coffee drinkers had a reduced risk of incident diabetes (odds ratio 0.38 [95% CI 0.170.87] and 0.36 [0.190.68], respectively) compared with those who never drank coffee. The 317 participants with baseline impaired glucose who were past or current coffee drinkers were also at reduced risk for incident diabetes (0.31 [0.110.87] and 0.36 [0.160.83], respectively). CONCLUSIONSThis study confirms a striking protective effect of caffeinated coffee against incident diabetes and extends these findings to incident diabetes based on OGTT independent of multiple plausible confounders.
Abbreviations: DBP, diastolic blood pressure FPG, fasting plasma glucose OGTT, oral glucose tolerance test PCG, postchallenge glucose SBP, systolic blood pressure
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