Abstract
MRgFUS (MR guided Focused Ultrasound) being one of the non-surgical ablation techniques. We have already achieved favorable results in the past clinical study of MRgFUS to local treatment. New twenty one cases of invasive/noninvasive ductal carcinoma of the breast were treated by MRgFUS. Core needle biopsy led to the definitive diagnosis. All the patients were positioned prone in the treatment, using the therapeutic apparatus such as Signa Excite 1.5T for MRI and ExAblate 2000 version 2.6/4.1 for FUS. Irradiation was not applied to all the 21 cases after MRgFUS. Axillary lymph node metastases were examined by dissection or sentinel lymph node biopsy. Recurrence or abnormal area of residual cancer was treated with Re-MRgFUS or ablated by usual surgery. All the 21 cases were from women patients. Median age is 54 years (range: 34–72). Median diameter of tumor is 15 mm (range: 5–50). As for the numbers of treatment, 17 patients were treated once, and 4 patients twice. Median period of observation is 14 months (range: 3–26). One case of recurrence of pure mucinous carcinoma was experienced. No evidences of recurrence were obtained through MRI for the rest of 20 cases. Skin burns were found in 2 cases. The patient had dimple on the skin immediately above tumor. In conclusion, MRgFUS is a good mean as local control of breast cancer, but the indicated case must be selected strictly. And it needs to observe longer the patients who ware treated by MRgFUS alone.
Similar content being viewed by others
References
Veronesi U, Banfi A, Saccozzi R, Salvadori B, Zucali R, Uslenghi C, Greco M, Luini A, Rilke F, Sultan L: Conservative treatment of breast cancer -A trial in progress at the National Cancer Institute of Milan-.Cancer 39:2822–2826, 1977.
Veronesi U, Banfi A, Salvadori B, Luini A, Saccozzi R, Zucali R, Marubini E, Del Vecchio M, Boracchi P, Marchini S, Merson M, Sacchini V, Riboldi G and Santoro G: Breast concervation is the treatment of choice in small breast cancer: long term results of randomized trial.Eur J Cancer 26:668–670, 1990.
Fisher B, Bauer M, Margolese R, Poisson R, Pilch Y, Redmond C, Fisher E, Wolmark N, Deutsch M, Montague E, Saffer E, Wickerham L, Lerner H, Glass A, Shibata H, Deckers P, Ketcham A, Oishi R and Russell I: Five-year result of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer.N Engl Med 312:665–673, 1985.
Gianfelice D, Khiat A, Amara M, Belblidia A, Boulanger Y: MR imaging-guided focused US ablation of breast cancer: histopathologic assessment of effectiveness - initial experience.Radiol 227:849–855, 2003.
Furusawa H, Namba K, Thomsen S, Akiyama F, Bendet A, Tanaka C, Yasuda Y, Nakahara H: MR-guided Focused Ultrasound Surgery of Breast Cancer: Reliability and Effectiveness.J Am Coll Surg 203:54–63, 2006.
Kaneko Y, Maruyama T, Takegami K, Watanabe T, Mitsui H, Hanajiri K, Nagawa H, Matsumoto Y: Use of a microbubble agent to increase the effects of high intensity focused ultrasound on liver tissue.Eur Radiol 15:1415–1420, 2005.
Kopelman D, Inbar Y, Hanannel A, Freundlich D, Vitek S, Schmidt R, Sokolov A, Hatoum OA, Rabinovici J: Magnetic resonance-guided focused ultrasound surgery using an enhanced sonication technique in a pig muscle model.Eur J Radiol 9:190–197, 2006.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Furusawa, H., Namba, K., Nakahara, H. et al. The evolving non-surgical ablation of breast cancer: Mr Guided focused ultrasound (MRgFUS). Breast Cancer 14, 55–58 (2007). https://doi.org/10.2325/jbcs.14.55
Published:
Issue Date:
DOI: https://doi.org/10.2325/jbcs.14.55