Vojnosanitetski pregled 2011 Volume 68, Issue 1, Pages: 41-45
https://doi.org/10.2298/VSP1101041R
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Decidual natural killer cells in recurrent spontaneous abortions
Radović-Janošević Dragana (Klinički Centar Niš, Klinika za ginekologiju i akušerstvo, Niš)
Lilić Vekoslav (Klinički Centar Niš, Klinika za ginekologiju i akušerstvo, Niš)
Bašić Hakija (Klinički Centar Niš, Institut za patologiju, Niš)
Tubić-Pavlović Aleksandra (Klinički Centar Niš, Klinika za ginekologiju i akušerstvo, Niš)
Stefanović Milan (Klinički Centar Niš, Klinika za ginekologiju i akušerstvo, Niš)
Milošević Jelena (Klinički Centar Niš, Klinika za ginekologiju i akušerstvo, Niš)
Background/Aim. A repeated or habitual miscarriage (PSP) is defined as three
or more consecutive losses of pregnancy. In the first three months of
pregnancy, habitual miscarriages occur in about 1% of pregnant women, out of
which 50% are of an unknown etiology. It is believed that among them, the
greatest number is the consequence of an inadequate alloimmune response of a
women to the pregnancy. The endocrine and immune systems are in a close
interaction during the implantation and maintaining of pregnancy. This
communication is the most obvious on endometrium of pregnancy decidua. The
aim of the study was to identify the number and the subpopulation
distribution of the decidual NK cells in the decidua by using an
immunohistochemical method. Methods. The research included a group of 30
women who had had two spontaneous miscarriages consecutively in the first
three months of their pregnancy, while the curettage after the third
spontaneous abortion was histopathologically and immunohistochemically
analyzed. The control group consisted of 20 women without a problematic
reproductive anamnesis, who had had their pregnancy terminated for social
reasons. The criteria for the eliminating from the research were the
diagnosed uterus anomalies, positive screening on thrombophilia, as well as
women suffering from diabetes melitus and the ones with the thyroid gland
function disorder. Results. The number and the phenotype structure of the
uterus NK cells were significantly different between the decidua of a normal
pregnancy and that in PSP. In the decidua in PSP, there were much more NK
cells with the phenotype of the peripheral circulation CD57 and CD56dim,
while in the decidua of the control group the dominant cells were the typical
uNK cell subpopulation CD56bright. Conclusion. The above mentioned results
show that the disregulation of the immunocompetent cells of the decidua, by
creating an inadequate cytokine milieu, is one of the mechanism of rejecting
the semiallogeneic blastocyst.
Keywords: abortion, habitual, abortion, legal, endometrium, killer cells, natural
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