Archives of Biological Sciences 2008 Volume 60, Issue 2, Pages: 163-168
https://doi.org/10.2298/ABS0802163O
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Effect of protamine sulfate on the isolated mesenteric arteries of normotensive and spontaneously hypertensive rats
Oreščanin-Dušić Zorana (Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd)
Milovanović S. (Medicinski fakultet, Univerzitet u Istočnom Sarajevu, Foča, Bosna i Hercegovina)
Spasić M. (Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd + Hemijski fakultet, Beograd)
Radojičić R. (Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd, + Biološki fakultet, Beograd)
Blagojević D. (Laboratorija za fiziologiju, Institut za biološka istraživanja 'Siniša Stanković', Beograd)
We tested the relaxant effect of increased protamine sulfate (PS) amounts (10, 20, 50, 100 and 150 μg/ml) on the isolated mesenteric arteries of normotensive and spontaneously hypertensive (SH) rats, with or without endothelium. PS caused concentration-dependent relaxation of isolated mesenteric arteries in both types of rats. The relaxation effect of PS was lower in SH rats than in normotensive ones. Our results indicate that the vascular smooth muscles play a significant role in PS-mediated relaxation.
Keywords: Protamine sulfate, mesenteric artery, hypertension, vascular endothelium, rats