Zbornik Matice srpske za prirodne nauke 2022 Issue 142, Pages: 61-71
https://doi.org/10.2298/ZMSPN2242061C
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Antimicrobial agents in laying hens
Ćupić Vitomir N. (The University of Belgrade, Faculty of Veterinary Medicine, Belgrade, Serbia), cpcv57@gmail.com
Ivanović Saša R. 
(The University of Belgrade, Faculty of Veterinary Medicine, Belgrade, Serbia)
Borozan Sunčica Z. (The University of Belgrade, Faculty of Veterinary Medicine, Belgrade, Serbia)
Mujezinović Indira A. (The University of Sarajevo, Faculty of Veterinary Medicine, Sarajevo, Bosnia and Herzegovina)
Ćupić-Miladinović Dejana V. (The University of Belgrade, Faculty of Veterinary Medicine, Belgrade, Serbia)
Aleksić Jelena Z. (The University of Belgrade, Faculty of Veterinary Medicine, Belgrade, Serbia)
The European Union permitted 6 antimicrobial agents that can be used in
laying hens. These are colistin, tyrosine, neomycin, oxytetracycline,
chlortetracycline, and erythromycin. Antimicrobial drugs are used today
primarily for the prevention and treatment of diseases in poultry and often
(not in the EU) to stimulate growth. Because these drugs are often used
irrationally, there are good chances that their residues will be found not
only in poultry meat but also in the eggs within a certain period after the
termination of treatment. In addition to the administration of authorised
VMPs, the residues in eggs can be the result of erroneously applied
medicated food, the contamination of the food with some antimicrobial drug
in the mixing unit, as well as “extra-label” use of drugs in poultry. The
antimicrobial agents are distributed in the body and deposited in the eggs,
mainly in the yolk where they persist longer than in the albumen. Drugs that
are poorly absorbed from the gastrointestinal tract (aminoglycosides,
aminocyclitols, polymyxins) cannot be detected in the eggs, while the
residues of some antimicrobial drugs can be detected for up to two months
(chloramphenicol) after the last treatment. The rational use of drugs in
veterinary medicine has manifold significance. When using drugs only when
they are really necessary (indicated), in the right dose and route of
administration, the potential damage can be reduced and efficiency
increased, while the risk of microorganism resistance development would be
significantly decreased. All of this becomes more important when these drugs
are used in food animals.
Keywords: antimicrobials, eggs, laying hens, residues, yolk, albumen
Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. TR46009
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