doiSerbia

Characteristics of gastric and duodenal mucosa in patients with primary biliary cholangitis

Popović Dragan (Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Clinic for Digestive Surgery, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Zgradić Sanja (Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Clinic for Digestive Surgery, Belgrade, Serbia)
Dragašević Sanja (Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Clinic for Digestive Surgery, Belgrade, Serbia)
Zec Simon (University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Micev Marijan (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Clinical Center of Serbia, Department of Pathology, Belgrade, Serbia)
Naumović Tamara (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + Institute of Public Health of Serbia “Dr Milan Jovanović Batut”, Belgrade, Serbia )
Milosavljević Tomica (Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Clinic for Digestive Surgery, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Alempijević Tamara (Clinical Center of Serbia, Clinic for Gastroenterology and Hepatology, Clinic for Digestive Surgery, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)

Background/Aim. Primary biliary cholangitis (PBC) is an immune-mediated chronic cholestatic disease of liver, with a slow progression. The aim of our study was to determine the correlation of PBC, atrophic gastritis (AG) and gluten-sensitive enteropathy (GSE), to identify the macroscopic and histopathological modifications of gastric and duodenal mucosa which occur in PBC and to analyze the frequency of these changes compared to a control group. Methods. This study included 50 patients with PBC and 46 control subjects with the dyspeptic symptoms, without liver disease. All of the examined subjects underwent esophagogastroduodenoscopy. Macroscopic and histopathological findings of the gastric and duodenal mucosal samples were recorded and analyzed. Results. There was no statistically significant association between the PBC and AG, or between the PBC and Helicobacter pylori infection. There was a highly significant difference in the frequency of Helicobacter pylori infection and the presence of GSE in the patients in the control group compared to those with PBC. Conclusions. The patients with PBC are at a lower risk for Helicobacter pylori infectionand atrophic gastritis. Testing for GSE in the PBC patients may be beneficial, considering the higher incidence of GSE amongst these patients. GSE represents a risk factor for the presence of PBC and the patients with GSE are nearly four times more likely to have PBC.

Keywords: liver cirrhosis, biliary, gastritis, atrophic, glutens, celiac disease, comorbidity, histology, helicobacter pylori