Vojnosanitetski pregled 2014 Volume 71, Issue 12, Pages: 1123-1127
https://doi.org/10.2298/VSP1412123M
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Subclinical hypothyroidism in children and adolescents after hematopoietic stem cells transplantation without irradiation
Milenković Tatjana (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Department of Endocrinology, Belgrade)
Vujić Dragana (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Pediatric HSCT Center, Belgrade + Faculty of Medicine, Belgrade)
Vuković Rade (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Department of Endocrinology, Belgrade)
Zečević Željko (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Pediatric HSCT Center, Belgrade)
Soldatović Ivan (Faculty of Medicine, Institute of Medical Statistics, Belgrade)
Mitrović Katarina (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Department of Endocrinology, Belgrade)
Todorović Slađana (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Department of Endocrinology, Belgrade)
Zdravković Dragan (Mother and Child Health Care Institute of Serbia “Dr Vukan Čupić”, Department of Endocrinology, Belgrade + Faculty of Medicine, Belgrade)
Background/Aim. Although total body irradiation (TBI) was considered to be
the primary cause of thyroid dysfunction following hematopoietic stem cells
transplantation (HSCT), a significant prevalence of subclinical
hypothyroidism after HSCT with chemotherapy-only conditioning regimens has
been observed in several studies. The aim of this study was to assess changes
in thyroid stimulating hormone (TSH) levels in children after HSCT, without
the use of irradiation at any time in the course of the treatment. Methods.
Our cohort consisted of 41 children and adolescents who underwent autologous
or allogeneic HSCT and were available for follow-up for at least one year
after transplantation. Irradiation was not performed in any of the subjects,
neither during pretransplatation therapy, nor during conditioning. The median
duration of follow-up was 2.9 years. The indications for HSCT were
hematologic malignancy (41.5%), solid malignant tumor (34.1%), and other
disorders (24.4%). The thyroid status of all the subjects was assessed prior
to HSCT and after follow-up period. Results. Thyroid dysfunction after HSCT
was present in 27 (65.8%) subjects. Subclinical hypothyroidism was the most
common abnormality, presenting in 23 (56.1%) patients, primary hypothyroidism
was present in one (2.4%) patient, while 3 (7.3%) subjects had low free T4
with normal TSH values. Significantly (p < 0.01) higher elevations in TSH
levels were present in the patients who received chemotherapy for the
underlying disease prior to HSCT. Conclusion. Our findings emphasize the need
for long-term monitoring of thyroid function following HSCT, regardless of
whether or not irradiation was used.
Keywords: hematopoietic stem cell transplantation, child, adolescent, hypothyroidism, radiotherapy