Vojnosanitetski pregled 2013 Volume 70, Issue 12, Pages: 1109-1116
https://doi.org/10.2298/VSP1312109M
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Risk factors for vancomycin-resistant Enterococcus colonization in hematologic patients
Mioljević Vesna (Clinical Center of Serbia, Department of Hospital Epidemiology and Hygiene, Belgrade)
Marković-Denić Ljiljana (Faculty of Medicine, Institute of Epidemiology, Belgrade)
Vidović Ana (Clinical Center of Serbia, Clinic of Hematology, Belgrade + Faculty of Medicine, Belgrade)
Jovanović Milica (Clinical Center of Serbia, Microbiology Department, Belgrade)
Tošić Tanja (Clinical Center of Serbia, Microbiology Department, Belgrade)
Tomin Dragica (Clinical Center of Serbia, Clinic of Hematology, Belgrade + Faculty of Medicine, Belgrade)
Background/Aim. Vancomycin-resistant Enterococci (VRE) is one of the most
important hospital pathogens. The aim of the study was to evaluate VRE
colonization in patients hospitalized at the Hematology Intensive Care Unit,
as well as the associated risk factors. Methods. A prospective cohort study
involved 70 patients hospitalized at the Intensive Care Unit (ICU), Clinic
for Hematology, Clinical Center of Serbia, Belgrade, during 3 months.
Baseline demographic data, data about antibiotic usage and other risk factors
for VRE colonization during the present and previous hospitalizations (within
6 months) were recorded for each patient using the questionnaire. Feces or
rectal swab was collected for culture from patients on admission and at
discharge in case when VRE was not isolated on admission. Enterococci were
isolated by standard microbiological methods. Isolate sensitivity was tested
by disk-diffusion test using 30 μg/mL (BBL) Vancomycin plates according to
the Clinical and Laboratory Standards Institute (CLSI) standard. Results.
Analysing results showed that 7% of the patients had been already colonized
with VRE upon ICU admission. The rate of VRE colonization during present
hospitalization was 41.5%. Univariate logistic regression demonstrated the
statistically significant differences in diagnosis, length of present stay,
use of aminoglycosides and piperacillin/tazobactam in present
hospitalization, duration of use of carbapenem and piperacillin/ tazobactam
in present hospitalization between the VREcolonized and non-colonized
patients. Acute myeloid leukemia (AML), use of carbapenem in previous
hospitalization and duration of use of piperacillin/tazobactam in present
hospitalization were independent risk factors for VRE-colonized patients
according to multivariate logistic regression. Conclusion. VRE colonization
rate was high among the patients admitted to hematology ICU. Rational use of
antibiotics and active surveillance may be helpful preventive measures
against the development of bacterial resistance to antimicrobial agents.
Keywords: enterococcus faecium, vancomycin, drug resistance, bacterial, hematologic diseases, risk factors
Projekat Ministarstva nauke Republike Srbije, br. 175046