Vojnosanitetski pregled 2013 Volume 70, Issue 10, Pages: 947-952
https://doi.org/10.2298/VSP1310947S
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Correlation between extraintestinal manifestations and clinical parameters with the histologic activity index in patients with inflammatory bowel diseases
Štulić Miloš (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade)
Ćulafić Đorđe (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Mijač Dragana (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Janković Goran (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Jovičić Ivana (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Krstić Miodrag (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Milosavljević Tomica (Clinical Center of Serbia, Clinic of Gastroenterology, Belgrade + Faculty of Medicine, Belgrade)
Bacground/Aim. Crohn's disease (CD) and ulcerative colitis (UC) are chronic,
idiopathic, inflammatory diseases of the digestive tract. The aim of this
study was to determine a possible correlation between the clinical
parameters of the disease activity degree and the presence of
extraintestinal manifestations with disease activity histopathological
degree, in patients presented with CD and UC. Methods. This cross-sectional
study included 134 patients (67 with CD and UC, respectively) treated at the
Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade. After
clinical, laboratory, endoscopic, histopathologic and radiologic
diagnostics, the patients were divided into two groups according to their
histopathological activity. The group I comprised 79 patients whose values
of five-grade histopathological activity were less than 5 (45 with CD and 34
with UC), while the group II consisted of 55 patients with the values higher
than 5 (22 with CD and 33 with UC). The CD activity index (CDAI) and
Truelove and Witts' scale of UC were used for clinical evaluation of the
disease activity. Results. CD extraintestinal manifestations were present in
28.9% and 63.6% of the patients in the groups I and II, respectively (p <
0.05). Comparison of the mean CDAI values found a significant difference
between these two patients groups (the group I: 190.0 ± 83.0, the group II:
263.4 ± 97.6; p < 0.05). No correlation of extraintestinal manifestations of
the disease, Truelove and Witts' scale and histological activity was found
in UC patients (p > 0.05). Conclusion. In the patients presented with CD,
the extraintestinal manifestations with higher CDAI suggested a higher
degree of histopathological activity. On the contrary, in the UC patients,
Truelove and Witts' scale and extraintestinal manifestations were not valid
predictors of the disease histopathological activity.
Keywords: Crohn disease, colitis, ulcerative, severity of illness index, signs and symptoms, histological techniques