doiSerbia

A case of primary peripheral T-cell type non-Hodgkin lymphoma originating in the iris: Clinico-pathological findings

Mihaljević Biljana
Sretenović Aleksandra
Jaković Ljubomir
Peruničić-Jovanović Maja
Kovačević Dragana
Rašić Dejan
Latković Zoran

Background. The ocular adnexal region is the primary localization of extranodal lymphoma in 5% to 15% of all Non-Hodgkin lymphoma. Intraocular lymphoma of T-cell origin is extremely rare and such sites of infiltration have been rarely observed in clinical examination. Case report. We presented a 56-year-old man with iris infiltration by primary intraocular peripheral T-cell lymphoma. The patient was in clinical stage I BE and the treatment was initiated according to cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone (CHOP) regimen. When the second course of the therapy was scheduled, the patient developed central nervous system lymphoma infiltration. Although De Angelis regimen was used, 3 months after the diagnosis was established, lethal outcome ensued due to disease progression. Conclusion. According to our experience we can conclude that further therapeutical approach to patients with primary intraocular Tcell lymphoma requires modification of conventional treatment regimens. The lower median survival in these patients suggests that the disease may be of more aggressive course.

Keywords: lymphoma, non-Hodgkin, iris diseases, diagnosis, neoplasm staging, histological techniques, therapeutics, treatment outcome.