doiSerbia

Drug utilization in treatment of thyroid disorders during pregnancy in Serbia

Horvat Olga (Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad)
Tomić Zdenko (Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad)
Mijatović Vesna (Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad)
Sabo Ana (Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Novi Sad)

Introduction. Depleted uranium radiation and pollution with polychlorinated biphenyls resulting from bombings the territories of Serbia as well as the additional long-term stress may have affected the function of thyroid gland. The objective of this study was to determine the trend of drug utilization in the treatment of thyroid dysfunction during pregnancy in Novi Sad. Material and Methods. Women who had given birth at the Department of Gynecology in 1989, 1999, 2007 and 2011 were interviewed during a one-month period about thyroid diseases in the pregnancy as well as the drugs they had taken. Results. Not a single pregnant woman was reported to have a thyroid disorder in 1989 and 1999, while in 2007 four women were reported to have a thyroid dysfunction. In 2011, fourteen out of 18 women with thyroid dysfunction were using levothyroxine and in most cases hypothyroidism was diagnosed as autoimmune Hashimoto thyroiditis. Conclusion. The study results suggest the necessity of performing more detailed analyses of the correlation between the frequency of the thyroid gland dysfunction and the effects of environmental pollution in Serbia.

Keywords: Thyroid Diseases, Pregnancy, Hashimoto Disease, Hypothyroidism, Propylthiouracil, Thyroxine, Risk Factors, Drug Therapy, Epidemiology, Serbia

Projekat Ministarstva nauke Republike Srbije, br. 41012