doiSerbia

Antimicrobial activity of some isatin-3-thiosemicarbazone complexes

Konstantinović Sandra S. (Tehnološki fakultet, Leskovac)
Radovanović Blaga C. (Prirodno-matematički fakultet, Odsek za hemiju, Niš)
Sovilj Sofija P. (Hemijski fakultet, Beograd)
Stanojević Svetlana (zdravlja, Biohemijska laboratorija, Leskovac)

Isatin-3-thiosemicarbazone complexes with Co(II), Ni(II), Cu(II), Zn(II), Hg(II) and Pd(II) were synthesized and evaluated for their antimicrobial activity against 7 pathogenic bacteria and 4 fungi. The complexes have an en­hanced activity compared to the ligand due to transition metal involved in coor­dination. The anti-amoebic activity in vitro was evaluated against the HM1:IMSS strain of Entamoeba histolytica and the results were compared with the standard drug, metronidazole. The preliminary test results showed that the complexes had better anti-amoebic activity than their respective ligands. Moreover, the com­plexes showed better inhibition of the test organism.

Keywords: isatin-3-thiosemicarbazone complex, antibacterial activity, antifungal activity, anti-inflammatory activity, anti-amoebic activity