Hemijska industrija 2015 Volume 69, Issue 1, Pages: 37-42
https://doi.org/10.2298/HEMIND130928014S
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Synthetic cinnamates as potential antimicrobial agents
Stefanović Olgica D. (Faculty of Science, Department of Biology and Ecology, Kragujevac)
Radojević Ivana D. (Faculty of Science, Department of Biology and Ecology, Kragujevac)
Čomić Ljiljana R. (Faculty of Science, Department of Biology and Ecology, Kragujevac)
This study deals with synthesis of methyl cinnamate, butyl cinnamate, and
p-methoxy methyl cinnamate and testing of their in vitro antimicrobial
activity. Antimicrobial activity was examined towards 29 microorganisms using
microdilution method. It is shown that antimicrobial activity of methyl
cinnamate and p-methoxy methyl cinnamate was better than that of butyl
cinnamate. Sarcina lutea, Bacillus subtilis ATCC 6633, B. subtilis and B.
subtilis IP 5832 (probiotic) were the most sensitive bacteria. It is
established that p-methoxy methyl cinnamate can be a new, potential
anti-Staphylococcus aureus agent with minimum inhibitory concentration of
62.5 μg/ml. Methyl cinnamate and p-methoxy methyl cinnamate inhibited the
growth of Aspergillus restrictus, A. flavus and A. fumigatus in the
concentration range from 62.5 μg/ml to 250 μg/ml.
Keywords: Methyl cinnamate, butyl cinnamate, p-methoxy methyl cinnamate, antimicrobial activity, bacteria, fungi