doiSerbia

Modeling the bioactive copper(II) complex stability by the use of an experimental design

Savić Ivana M. (Faculty of Technology, Leskovac)
Nikolić Goran S. (Faculty of Technology, Leskovac)
Savić Ivan M. (Faculty of Technology, Leskovac)
Cakić Milorad D. (Faculty of Technology, Leskovac)
Došić Aleksandar (Faculty of Technology, University of East Sarajevo, Zvornik, Bosnia and Herzegovina)
Canadi Janos (Faculty of Sciences, Department of Chemistry, Novi Sad)

A new organic-inorganic complex based on copper ions with pullulan polysaccharide can be used for the treatment of copper deficiency in human organism. Therefore, the aim of this paper was to carry out the stress stability study of this potential active substance by the use of mathematical modelling. A full factorial design was successfully applied for the stability studying. The electrical conductivity was taken as the response, while the degradation time, concentration of the oxidative agent, temperature, and pH value were used as the independent variables. All process variables were analyzed at the three levels. On the basis of statistical analysis of data for the thermal stability study, the temperature and degradation time had the main impact on the conductivity of the complex solution. The degradation time had the significant effect in the case of oxidative stability study. In addition to the degradation time, the pH value and the temperature had the significant effect on the complex stability for the hydrolytic stability study.

Keywords: modeling, copper-pullulan complex, stability