Chemical Industry and Chemical Engineering Quarterly 2011 Volume 17, Issue 1, Pages: 39-44
https://doi.org/10.2298/CICEQ100524051M
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Non-specific methods for detecting residues of cleaning agents during cleaning validation
Milenović Dragan M.
Pešić Dragan S.
Mitić Snežana S.
Cleaning validation procedures are carried out in order to assure that
residues of cleaning agents are within acceptable limits after the cleaning
process. Cleaning agents often consist of a mixture of various surfactants
which are in a highly diluted state after the water rinsing procedure has
been completed. This makes it difficult to find appropriate analytical
methods that are sensitive enough to detect the cleaning agents. In addition,
it is advantageous for the analytical methods to be simple to perform and to
give results quickly. In this study, three different non-specific analytical
methods are compared: visual detection of foam, pH and conductivity
measurements. The analyses were performed on different dilutions of the
cleaning agents Bactericidal Hydroclean and Tickopur R33. The results
demonstrated that the most appropriate method for these detergents is
conductivity measurements, by which it is possible to detect concentrations
of cleaning agents down to 10 μg/ml. In these case, pH is inadequate method
(non-linear) and visual detection of foam is a semi-quantitative method. All
these methods are easy to perform, gives a quick results, and requires no
expensive instrumentation.
Keywords: detergents, cleaning validation, residues, swab analysis
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