doiSerbia

The influence of certain molecular descriptors of fecal elimination of angiotensin II receptor antagonists

Trbojević-Stanković Jasna B. (School of Medicine, Belgrade + Clinical Hospital Center "Dr Dragiša Mišović", Department of Dialysis, Belgrade)
Odović Jadranka V. (Faculty of Pharmacy, Department of Analytical Chemistry, Belgrade)
Jelić Ratomir M. (Faculty of Medicinal Science, Kragujevac)
Nesić Dejan M. (School of Medicine, Institute of Medical physiology, Belgrade)
Stojimirović Biljana B. (School of Medicine, Belgrade + Clinical Center of Serbia, Clinic of Nephrology, Belgrade)

Angiotensin II receptor antagonists (ARBs) modulate the function of the renin-angiotensin-aldosterone system and are commonly prescribed antihypertensive drugs, especially in patients with renal failure. In this study, the relationship between several molecular properties of seven ARBs (candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan, valsartan) and their fecal elimination data obtained from the literature were investigated. The ARB molecular descriptors were calculated using three software packages. Simple linear regression analysis showed the best 2 correlation between fecal elimination data and lipophilicity descriptor, ClogP values (R2 = 0.725). Multiple linear regression was applied to examine the correlation of ARBs’ fecal elimination data with their lipophilicity and one additional, calculated descriptor. The best correlation (R2 = 0.909 with an acceptable probability value, P <0.05) was established between the ARB fecal elimination data and their lipophilicity and aqueous solubility data. Applying computed molecular descriptors for evaluating drug elimination is of great importance in drug research.

Keywords: angiotensin II receptor antagonists, lipophilicity, aqueous solubility, fecal elimination