doiSerbia

Understanding the relevance of pain, depression and anxiety-like manifestations in the management of cystic fibrosis

Moraru Evelina (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Diaconu Ramona (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Anton Emil (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Bozomitu Laura (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Anton Carmen (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Alin Ciobica ("Alexandru Ioan Cuza" University, Iasi, Romania + Center of Biomedical Research of the Romanian Academy, Iasi Branch, Iasi, Romania)
Timofte Daniel (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Oprisa Cristina (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)
Azoicai Alice (Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania)

Cystic fibrosis (CF) is the most frequent autosomal recessive genetic disease in Caucasians. Although epidemiological studies continue to provide data and information that could lead to a better understanding of the clinical manifestations of the disease, there are still many controversies regarding the importance of some risk factors, such as pain, depression or anxiety in the pathogenesis of this disorder and its management. In the present study, we focused on the relevance of these 3 factors in the management of CF and to their related mechanisms in this disorder. Our original data showed that pain, depression and anxiety, determined by using a specific quality of life (KINDL) questionnaire, are important in understanding this disorder, the effectiveness of treatment and could also represent important factors for improving treatment. The screening and treatment of these specific manifestations in CF patients is recommended and holds promise for improving the outcome of patients with CF.

Keywords: cystic fibrosis, pain, depression, anxiety