Archives of Biological Sciences 2012 Volume 64, Issue 4, Pages: 1383-1388
https://doi.org/10.2298/ABS1204383K
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The prevalence of human polyomaviruses in urine samples of immunocompetent individuals in the Serbian population
Karalić Danijela (Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade)
Lazarević Ivana (Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade)
Ćupić Maja (Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade)
Jovanović Tanja (Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade)
The BK (BKV) and JC viruses (JCV) are human polyomaviruses. After primary
infection, they persist as latent infection in the kidneys. Immunosuppression
leads to their reactivation, which is associated with life-threatening
diseases such as polyomavirus-induced nephropathy and progressive multifocal
leukoencephalopathy. However, the behavior of these viruses in
immunocompetent individuals is still an open question with no right answer.
The aim of this study was to determine the prevalence of BKV and JCV shedding
in the urine of immunocompetent individuals from the Serbian population.
Sixty-five urine samples were collected and tested for the presence of BKV
and JCV DNA by PCR. JCV DNA was detected in 19/65 (29.2%) and BKV DNA in 3/65
(4.6%) of the urine samples. Forty-three (66.2%) urine samples of the
immunocompetent donors were negative for both viruses. The present study
provides the first results of urinary excretion of human polyomaviruses in
the Serbian population.
Keywords: human polyomaviruses, immunocompetent, urinary excretion
Projekat Ministarstva nauke Republike Srbije, br.
175073