Archives of Biological Sciences 2012 Volume 64, Issue 4, Pages: 1271-1276
https://doi.org/10.2298/ABS1204271M
Full text ( 521 KB)
Cited by
First case of visceral Leishmaniosis/HIV coinfection in Niš - southeastern Serbia
Marjanović G. (Medical Faculty, Niš + Clinical Center Niš, Niš)
Miladinović-Tasić Nataša (Medical Faculty, Niš + Institute of Public Health Niš, Niš)
Gabrielli Simona (“Sapienza” University of Rome, Medical Faculty, Rome, Italy)
Otašević Suzana (Medical Faculty, Niš + Institute of Public Health Niš, Niš)
Popović-Dragonjić Lidija (Medical Faculty, Niš + Clinical Center Niš, Niš)
Kocić Branislava (Medical Faculty, Niš + Institute of Public Health Niš, Niš)
Arsić-Arsenijević Valentina (Medical Faculty, Belgrade)
Tadić Ljiljana (Military Hospital, Niš)
Cancrini Gabriella (“Sapienza” University of Rome, Medical Faculty, Rome, Italy)
Visceral leishmaniosis (VL) has emerged as an important opportunistic
parasitosis associated with human immunodeficiency virus (HIV) infection. The
aim of this paper is to report the first case of Leishmania/HIV coinfection
in a patient from Niš (Southeastern Serbia). Microscopical examination of
Giemsa-stained bone marrow (BM) smears show the presence of Leishmania spp.
amastigotes based on their morphological characteristics. In spite of the
parasitological finding, the serological test applied gave negative results.
Molecular analyses confirmed the infection and allowed us to identify the
leishmania species as Leishmania infantum (100% identity). VL/HIV coinfection
has important clinical, diagnostic and epidemiological implications. In fact,
the failure of serological tests is expected in this condition, and the
application of molecular diagnostics to the blood may offer, apart from an
easy and non-invasive diagnostic opportunity, the possibility of warning
about the risk of possible nosocomial infections.
Keywords: Visceral leishmaniosis, HIV co-infection, molecular diagnosis
Projekat Ministarstva
nauke Republike Srbije, br. 41018 and br. 175034