Archives of Biological Sciences 2007 Volume 59, Issue 4, Pages: 303-309
https://doi.org/10.2298/ABS0704303S
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Apolipoprotein B gene polymorphisms in patients from Serbia with ischemic cerebrovascular disease
Stanković Aleksandra 
(Institut za nuklearne nauke "Vinča", Beograd)
Stanković Sanja (Institut za medicinsku biohemiju, Klinički centar Srbije, Beograd)
Jovanović-Marković Zagorka (Institut za neurologiju, Klinički centar Srbije, Beograd)
Živković Maja (Institut za nuklearne nauke "Vinča", Beograd)
Đurić Tamara (Institut za nuklearne nauke 'Vinča', Beograd)
Glišić-Milosavljević Sanja (Institut za nuklearne nauke 'Vinča', Beograd)
Alavantić D. (Institut za nuklearne nauke 'Vinča', Beograd)
The plasma concentration of apoB has recently been reported to be the best lipid predictor of coronary heart disease. The possible associations of genetic markers in the apolipoprotein B gene (XbaI, EcoRI, MspI, Ins/Del, and 4311 A/G polymorphisms) were evaluated in patients with ischemic cerebrovascular disease (ICVD) and controls of equivalent BMI. The odds ratio for ICVD in the X+X+ genotype was 2.22, 95% CI 1.24-3.96 (P<0.05), while that for ICVD in the Ins/Ins genotype was 2.82, 95% CI 1.57-5.06 (P<0.05). The patients had significantly higher frequency of the 4311A allele compared to the controls (P<0.01). Our results support the assumption that apoB gene polymorphisms may contribute to the extent of cerebrovascular disease risk.
Keywords: ApoB, ischemic cerebrovascular disease, gene, polymorphism, human population, Serbia