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KRAS SNPs are related to colorectal cancer susceptibility and survival in Chinese people

    XiuLan Liu

    Department of Pathology, Second People's Hospital of Neijiang, Neijiang, 641100 Sichuan, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Guangji Yang

    Department of Gynecology, First People's Hospital of Yunnan Province, Kunming, 650032 Yunnan, PR China

    Authors contributed equally

    Search for more papers by this author

    ,
    Juan Huang

    Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, PR China

    ,
    Li Chai

    Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, PR China

    ,
    Xun Liu

    Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, PR China

    ,
    Qiong Dai

    Department of Human Anatomy, Southwest Medical University, Luzhou, 646000 Sichuan, PR China

    &
    ZhiHui Yang

    *Author for correspondence: Tel.: +86 830 316 2062; Fax: +86 830 316 0331;

    E-mail Address: yzhih73@swmu.edu.cn

    Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, PR China

    Published Online:https://doi.org/10.2217/bmm-2019-0172

    Aim:KRAS SNPs may increase KRAS transcription and KRAS levels. SNPs of KRAS 3′UTR can affect carcinoma risk and prognosis. Materials & methods: The rs8720 and rs7960917 in KRAS 3′UTR for colorectal carcinoma (CRC) risk and survival were investigated in a case–control study. Association between SNPs and CRC risk, survival analysis were analyzed by an unconditional logistic regression model, log-rank test, Kaplan–Meier estimation, Cox regression model and one-way analysis of variance. Results & conclusion: The genotype CT of rs8720 was significantly increased risk of CRC, decreased overall survival and event-free survival, and KRAS mRNA and protein expressions were significantly increased in individuals with rs8720 CT, TT genotype. rs8720 may be an important factor in CRC development and prognosis.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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