COUROUPITA GUIANENSIS: THE RESERVOIR OF MEDICINAL COMPOUNDS OF HUMAN WELFARE
DOI:
https://doi.org/10.22159/ajpcr.2017.v10i3.16174Abstract
ABSTRACT
Medicinal plants play a role in the traditional form of providing relief to several diseases. Couroupita guianensis is also a type of medicinal plant
which has antibacterial, antimycobacterial, antimicrobial, antioxidant, antitumor, antiulcer, antinociceptive, anthelmintic, antifertility, and antifungal
activities. The chemical constituent of C. guianensis such as indirubin serves as an antibacterial and antifungal agent because it particularly cures
fungal diseases. It is active for the treatment of chronic myelocytic leukemia. The extract of isatin from the flower of C. guianensis is also a chemical
component that has been used as prophylactic agent, prevents free radial-induced cancer, acts as a chemotherapeutic agent to kill cancer cells, and it
has antioxidant (act as major defense) and anticancer activities against human promylocytic leukemia 60 cells. The extract of chloroform of fruit of
C. guianensis shows good antimicrobial activity but low antimycobacterial activity. The plant extract of C. guianensis is equipotent to standard drugs
such as paracetamol in its analgesic activity and indomethacin in its anti-inflammatory activity.
Keywords: Couroupita quianensis, Antibacterial activity, Anti tumor activity, Antioxidant activity, Anti biofil.
Downloads
References
REFERENCES
Satyavati GV, Raina MK. Medicinal Plants of India. Vol. 1. New Delhi: Indian Council of Medical Research. p. 286.
Sundarajan R, Koduru R. A complete profile of Couroupita guianensis–traditional uses pharmacological activities and phytoconstituents. Pharmacophore 2014;5(1):147-59.
Wong KC, Tie DY. Volatile constituents of Couroupita guianensis Aubl. Flowers. J Essent Oil Res 1995;7:225-7.
Rane JB, Vahanwala SJ, Golatkar SG, Ambaye RY, Khadse BG. Chemical examination of the flowers of couroupita guianensis Aubl. Indian J Pharm Sci 2001;63:72-3.
Bergman J, Lindstrom JO, Tilstam U. The structure and properties of some indolic constituents in Couroupita guianensis Aubl. Tetrahedron 1985;41:2879-81.
Sen AK, Mahato SB, Dutta NL, Couroupitine A. A new alkaloid from couroupita guianensis. Tetrahedron Lett 1974;7:609-10.
Row LR, Santry CS, Suryananayana PP. Chemical examination of couroupita guianensis. Curr Sci 1966;35(6):146-7.
Anjaneyulu AS, Rao SS. A new ketosteroid from the bark of Couroupita guianensis Aubl. Indian J Chem B Org Chem 1998;37(9-12):382-6.
Al-Dhabi NA, Balachandran C, Raj MK, Duraipandian V, Muthukumar C, Ignacimuthu S, et al. Antimicrobial, antimycobacterial and antibiofilm properties of Couroupita guianensis Abul. Fruit extract. BMC Complement Altern Med 2012;12:242.
Singh R, Kumari N, Gangwar M, Nath G. Qualitative characterization of phytochemicals and in vitro antimicrobial evaluation of leaf extract of Couroupita guianensis Aubl. - A threatened medicinal tree. Int J Pharm Pharm Sci 2015;7(7):212-5.
Gousia SK, Kumar KA, Kumar TV, Latha JN. Biological activities and medicinal properties of Couroupita guianensis. Int J Pharm Pharm Sci Res 2013;3(4):140-3.
Kumar CS, Naresh G, Sudheer V, Veldi N, Elumalai A. A short review on therapeutic uses of Couroupita guianensis Aubl. Int Res J Pharm Appl Sci 2011;1(1):105-8.
Sivakumar T, Shankar T, Vijayabaskar P, Geetha G. Efficacy of Couroupita guianensis against selected human pathogens. Adv Biol Res 2012;6(2):59-63.
Shah GN, Shete SA, Patil SA, Patil KD, Killedar SG. Standardization and antibacterial activity of Couroupita guianensis fruit pulp extract. Int J Pharm Phytochem Res 2012;4(4):185-9.
Azimi H, Fallah-Tafti M, Khakshur AA, Abdollahi M. A review of phytotherapy of acne vulgaris: Perspective of new pharmacological treatments. Fitoterapia 2012;83(8):1306-17.
Regina V, Rajan KM. Phytochemical analysis, antioxidant and antimicrobial studies of fruit rind of Couroupita guianensis. Int J Curr Sci 2012;221:262-7.
Ramalakshmi C, Ranjitsingh AJ, Kalirajan K, Kalirajan A, Athinarayanan G, Mariselvam R. A preliminary screening of the medicinal plant Couroupita guianensis for its antimicrobial potential against clinical and fish-borne pathogens. Elixir Appl Biol 2013;57:14055-7.
Hoessel R, Leclerc S, Endicott JA, Nobel ME, Lawrie A, Tunnah P, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1999;1(1):60-7.
Leclerc S, Garnier M, Hoessel R, Marko D, Bibb JA, Snyder GL, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem 2001;276(1):251-60.
Perabo FG, Landwehrs G, Frössler C, Schmidt DH, Mueller SC. Antiproliferative and apoptosis inducing effects of indirubin-30-monoxime in renal cell cancer cells. Urol Oncol 2009;29(6):815-20.
Perabo FG, Frössler C, Landwehrs G, Schmidt DH, von Rücker A, Wirger A. Indirubin-30-monoxime, a CDK inhibitor induces growth inhibition and apoptosis-independent up-regulation of survivin in transitional cell cancer. Anticancer Res 2006,26:2129-35.
Marko D, Schätzle S, Friedel A, Genzlinger A, Zankl H, Meijer L. Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin analogs in human tumour cells. Br J Cancer 2001;84(2):283-9.
Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedlocha A. Indirubin-3’-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. Oncogene 2007;26(44):6372-85.
Umachigi SP, Jayaveera KN, Ashok KC, Kumar GS. Antimicrobial, wound healing and antioxidant potential of Couroupita guianensis in rats. Pharm Online 2007;3:269-81.
Bafna AR, Mishra SH, Deoda RS, Bafna PA, Kale RH. In vitro antioxidant activity of ethyl acetate fraction of water extract of flowers of Couroupita guianensis. Int J Pharm Pharm Sci 2011;3(4):4-6.
Premanathan M, Radhakrishnan S, Kulangiappar K, Singaravelu G, Thirumalaiarasu V, Sivakumar T, et al. Antioxidant & anticancer activities of isatin (1H-indole-2,3-dione), isolated from the flowers of Couroupita guianensis Aubl. Indian J Med Res 2012;136(5):822-6.
Prabhu V, Ravi S. Quantification of quercetin and stigmasterol of Couroupita guianensis AUBL by HPTLC method and in vitro cytotoxic activity by MTT assay of the methanol extract against HeLa, NIH3T3 and HepG2 cancer cell lines. Int J Pharm Pharm Sci 2012;4(4):126-30.
Elumalai A, Eswaraiah MC, Didala A. Investigations on antioxidant, an antiarthritic and antiplatelet study in Couroupita guianensis aubl leaves by in vitro methods. 2012;3(3):2262-9.
Pinheiro MM, Fernandes SB, Fingolo CE, Boylan F, Fernandes PD. Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves. J Ethnopharmacol 2013;146(1):324-30.
Geetha M, Saluja AK, Shankar MB, Mehta RS. Analgesic and anti-inflammatory activity of Couroupita guianensis Aubl. J Nat Remedies 2004;4(1):52-5.
Despax B, Saulou C, Raynaud P, Datas L, Mercier-Bonin M. Transmission electron microscopy for elucidating the impact of silver versus nanosilver- containing coating on the model yeast Saccharomyces cerevisiae. Nanotechnology 2011;22(17):175101.
Rajarathinam M, Girilal M, Peter M, Kalaichelvan PT. Augmentation potential antifungal activity of Gandhaka rasayanam (a Siddha compound) using green synthesized silver nanoparticles from Couroupita guianensis leaf extract against selected pathogenic strain. Int Res J Pharm 2013;4(6):234.
Subramaniam J, Murugan K, Panneerselvam C, Kovendan K, Madhiyazhagan P, Dinesh D, et al. Multipurpose effectiveness of Couroupita guianensis-synthesized gold nanoparticles: High antiplasmodial potential, field efficacy against malaria vectors and synergy with Aplocheilus lineatus predators. Environ Sci Pollut Res Int 2016;23(8):7543-58.
Vimala RT, Sathishkumar G, Sivaramakrishnan S. Optimization of reaction conditions to fabricate nano-silver using Couroupita guianensis Aubl. (Leaf & fruit) and its enhanced larvicidal effect. Spectrochim Acta A Mol Biomol Spectrosc 2015;135:110-5.
Sathishkumar G, Pradeep KJ, Vignesh V, Rajkuberan C, Jeyaraj M, Selvakumar M. Cannonball fruit (Couroupita guianensis, Aubl.) Extract mediated synthesis of gold nanoparticles and evaluation of its antioxidant activity. J Mol Liq 2016;215:229-36.
Kumar TV, Murthy JS, Rao MN, Bhargava Y. Evaluation of silver nanoparticles synthetic potential of Couroupita guianensis Aubl., Flower buds extract and their synergistic antibacterial activity. 3 Biotech 2016;6(1):92.
Published
How to Cite
Issue
Section
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.
