We conducted numerical simulations in the coastal region of Sendai Bay for tsunami flood and chemical transport generated by the Great East Japan Earthquake, and discussed the applicability of the numerical simulations to early determination of spatial distribution of chemical pollution in tsunami deposit. The chemical transport simulation considered the spatial distribution of the storage facilities as the point sources of harmful chemicals. The tsunami-flood model reproduced the observed results of the tsunami waveforms at the wave gauges and the flood depth in the land. The simulated results of the chemical transport could roughly capture the region with the chemical pollution in the tsunami deposit, which implied that the numerical procedure could be useful for early zoning of the chemical pollution in tsunami deposit. The point source information should be improved to determine the chemical polluted area more accurately.